By Annie M. Young, Richard Hobbs, David J. Kerr

Many advances within the therapy of eye stipulations have taken position because the 3rd variation of ABC of Eyes was once released. This publication takes a symptom-based method of the therapy and prognosis of eye difficulties. it's been absolutely up-to-date with an elevated model of the bankruptcy on refractive error and sections on glaucomas rewritten. new chapters were additional on age-related macular degeneration and the worldwide impression of eye problems.

This best-selling ABC may be a useful source for an individual who offers with eye difficulties in basic care or in an emergency division.

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Recent surveys, however, have highlighted the lack of consensus among surgeons about the optimal modality and intensity of follow up; surveillance strategies range from a single postoperative visit to lifelong surveillance. Enthusiasts believe that intensive follow up and early intervention will lead to a reduction in the number of deaths from colorectal cancer; others point to the fact that the value of follow up is unproved. With so many tests available and no consensus on their value, it is not surprising that individual clinicians have tended to devise their own protocols.

Controversies in adjuvant therapy Despite convincing evidence that adjuvant chemotherapy improves disease-free survival and overall survival in Dukes’s type C colon cancer (an estimated six deaths prevented for 100 patients treated), several controversies surrounding the application of this form of treatment still exist. Length of treatment and optimal dose of fluorouracil plus folinic acid Lengthy adjuvant treatment has adverse effects on patients’ quality of life as well as financial implications.

The authors acknowledge the support of the Cancer Research Campaign and the Medical Research Council. The survival graph is adpated from the Lancet (2000;355:1588-96); the illustration of microscopic metastasis was supplied by Dr D C Rowlands. 25 8 Treatment of advanced disease Annie M Young, Daniel Rea Advanced colorectal cancer can be defined as colorectal cancer that at presentation or recurrence is either metastatic or so locally advanced that surgical resection is unlikely to be carried out with curative intent.

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