By George F. Vande Woude

Advances in melanoma learn presents worthwhile details at the fascinating and fast-moving box of melanoma learn. the following, once more, amazing and unique studies are provided on a number of issues

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This situation represents the acute phase of the disease. CYC administration irrespective of CYC dose levels triggered the disappearance of plasma tumor cells from the BM area (replaced by the normal BM population) and markedly prolonged their survival (150–220 days vs. 61–95 days survival of the controls), thereby reverting the disease development to a chronic phase. p. CYC (mg/Kg) Timing of BM transfer from donor mice (days post CYC injection) MM incidence in BM of recipient mice (n/n, %) Mean (Æ SD) latency of recipient mice (days) 60 60 60 66 70 0 100 200 100 100 80 170 170 196 240 5/5, 100% 0/10, 0% 10/10, 100% 4/10, 40% 1/10, 10% 61Æ5 220 111Æ14 170Æ20 142 aBM (2Â107/mouse) from 5T2MM injected mice treated with CYC that did not develop overt disease for a prolonged period was transferred to young normal syngeneic recipients (from one donor to one recipient) and followed for MM development in the BM recipient for 220 days.

The spleen was always the main site of lymphoma development, usually involving an enlarged spleen (two- to eightfold weight): the involvement of lymph nodes was observed in 50% of these sick mice and sometimes small foci were observed in the liver; however, their BM was always normal. In several mice (9/30) besides the lymphoma, small foci of plasma tumor cells were observed in the spleen and lymph nodes. V. CONCLUDING REMARKS A major impediment to cancer immunotherapy is tumor-induced suppression and tumor evasion of antitumor immune response, which ultimately render the host tolerant to tumor-associated antigens.

Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J. Exp. Med. 200, 771–782. , Vidriales, M. , Dedera, D. , Schlossman, R. , and Anderson, K. C. (1996). Transforming growth factor-beta1: Differential effects on multiple myeloma versus normal B cells. Blood 87, 1928–1938. , and Van Camp, B. (1997). Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse. Br. J. Cancer 76, 451–460. Vu, M. , and Chang Li, X.

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