By Dr. Monique Dubois-Dalcq, Professor Dr. Kathryn V. Holmes, Dr. Bernard Rentier (auth.)

This e-book is a set of severe studies a few different team of virus households with positive factors in universal: the sturdy repository of genetic info in every one virus is RNA, and every virus modifies and appropriates a selected patch of the eukaryotic mobilephone membrane method to accomplish its constitution. The reports take the reader from the extent of virus genome constitution and expression throughout the quaternary interactions among virus-specified components and mobile parts that cooperate to supply virus debris. There are remarkable illustrations during this quantity, however it is way greater than an image gallery. examining commonly during this booklet will be an efficient antidote to overspecialization: in those pages, you are going to examine a lot approximately viruses and approximately cells that you simply did not understand prior to; you will discover illuminating parallels among diversified virus households; you will come away with a sharpened knowledge of vital issues which are nonetheless to be discovered. Memphis, Tenn. , summer time 1984 David W. Kingsbury Preface This ebook was once written on the advice of Dr. David W. Kingsbury made at a piece­ store on viruses geared up by means of the a number of Sclerosis Society in Aspen, Colorado, U. S. A. , 3 years in the past. initially, we had idea to target the morphological points of viral meeting. Later, in the course of our discussions at the means of budding of enveloped RNA viruses, it grew to become obtrusive that we must always comprise biochemical information in our evaluate and correlate them with the structural features of virus maturation.

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Compare to Fig. 2-4b. Magnification: (a) X 36,000; (b) X 87,100. (Courtesy of Drs. F. A. Murphy andA. K. , Assembly 33 34 Assembly of Rhabdoviridae Fig. 2-6. Intracellular budding of an Ethiopian canine rabies virus strain. The virus is mostly budding from membranes of the endoplasmic reticulum. Magnification X 77,200. [Courtesy of Dr. A. K. , 1982. (Reproduced with permission of Springer-Verlag, Wien)] Assembly of Virus Components 35 brane proteins for incorporation into the virion. Such virions are spikeless, as in ts 045 infection (Schnitzer and Lodish, 1979).

18 An Overview of the Assembly of Enveloped RNA Viruses feron, these clustering events appear to be hampered, perhaps by alteration of membrane fluidity and/or submembraneous structures. , 1980). As a result, interferon may inhibit various steps in final assembly of retro- and rhabdoviruses, including budding and incorporation of virus glycoproteins (Friedman, 1977). The mechanisms of this inhibition are probably multiple, but, in the case of some retroviruses, the apparent inhibition of clustering and release is definitely not related to a defective interaction between NC and viral envelope proteins or to defective cleavage of gag proteins (Sen and Pinter, 1983) (see Chapter 9).

The Pneumoviruses have a similar glycoprotein but are devoid of both hemagglutinatnig and neuraminidase activities. (6) Fo Protein (MW: 65 K to 68 K). Fo is the precursor of the FI and F2 subunits of the surface glycoprotein F (Samson and Fox, 1973; Scheid and Choppin, 1974). F2 is smaller than FI but contains a higher concentration of carbohydrates (Scheid and Choppin, 1977). These two polypeptide chains are linked by disulfide bonds and form the active F protein. F is responsible for the fusion of the virus envelope with the plasma membrane of its target cell, hence F is required for virus penetration.

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