By Kivie Moldave, Sankar Mitra, Amanda K. McCullough, R. Stephen Lloyd, Samuel H. Wilson (Eds.)
This quantity of development in Nucleic Acid study and Molecular Biology represents study mentioned in the course of the DNA Base Excision fix Workshop. This compilation of articles specializes in a number of contemporary observations highlighting the complexity of the bottom excision fix (BER) strategy in DNA fix. concentrating on some of the elements of BER study, this publication is a well timed and hugely helpful reference for investigators within the DNA fix box. it's going to additionally reduction scientists in some way occupied with fix reports to procure a complete realizing of the present country of information within the box.
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4 9 9 20 21 23 24 25 To preserve genomic/~ DNA from common endogenous and exogenous base and sugar damage, cells are provided with multiple base excision repair (BER) pathways: the DNA polymerase (Pol)/~-dependent single nucleotide BER and the long-patch (2-10 nt) BER that requires PCNA. It is a challenge to identify the factors that govern the mechanism of switching among these pathways. One of these factors is the type of DNA damage induced in DNA. By using different model lesions we have shown that base damages (like hypoxanthine and 1, Na-ethenoadenine) excised by monofunctional DNA glycosylases are repaired via both single-nucleotlde and long-patch BER, while lesions repaired by a bifunctional DNA glycosylase (like 7,8-dihydro-8-oxoguanine) are repaired mainly by single-nucleotide BER.
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