By E. Diczfalusy (auth.), Professor Dr. A. A. Haspels, Professor Dr. R. Rolland (eds.)

A. A. Haspe/s it really is with excitement that I welcome you, on behalf of Professor Rolland and myself, to Amsterdam for this foreign Symposium on 'Benefits and dangers of Hormonal Contraception'. As a way offamily making plans the capsule is set 25 years previous - a timespan which has been characterised through a massive raise in public curiosity and situation with kinfolk healthiness and family-planning. absolutely now we have discovered much during the last 25 years. As you notice in determine 1, within the seventies in Holland fairly extra fertile girls used the tablet than in the other state on the planet. In 1974 new mixture tablets have been brought containing lower than 50 JAg of ethinyl estradiol. In 1981 50 % of Dutch capsule­ clients took a sub-50 (Figure 2). a similar is right for the Scandi­ navian nations. In our personal collage hospital ninety five % of pill-users take a sub-50 tablet; purely five % use a 50 JAg tablet on clinical indication. This lessen in estrogen dosage, that's frequently followed via a lessen of progestational part to boot, has ended in a reduce of thromboembolic affliction. elements which are nonetheless vital to think about are diabetes mellitus, high blood pressure, adipositas and smoking. wide array of sufferers including the prescribing the place attainable of sub-50 capsules may end up within the numbers of compli­ cations and side-effects being with reference to these encountered within the keep watch over group.

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S. and Stolley, P. D. (1981). Risk of myocardial infarction in relation to current and discontinued use of oral contraceptives. N. Engl. J. Med. , 305, 420 12. Shearman, R. P. (1981). Oral contraceptives: where are the excess deaths? Med. J. , 1, 698 13. Bottiger, L. , Eklund, G. and Westerholm, B. (1980). Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content. Lancet, 1, 1097 14. Royal College of General Practitioners' Oral Contraception Study (1981). Further analyses of mortality in oral contraceptive users.

In February 1973, oral contraceptives became available as a pharmaceutical benefit item and within 2 years one third of Australian women of reproductive age were using hormonal contraception (Table 2). In 1977, a further temporary downward trend in sales was again noted, with the release of the report of circulatory system disease in association with oral contraceptive usage. However, 35 BENEFITS AND RISKS OF HORMONAL CONTRACEPTION as had been observed following the adverse publicity earlier in the decade, such a slump was to be temporary only and the total number of prescriptions written in Australia has once again slowly but steadily increased.

3 % of the total cycles in women using the fixed dose combination. During the course of treatment a f:ontinuous transition from longer and heavier menstruations to shorter and scantier ones was observed by the patients in both groups. Bleeding irregularities, such as spotting and/or breakthrough bleedings occurred more frequently on the 43 BENEFITS AND RISKS OF HORMONAL CONTRACEPTION 30/150/ig pill compared with the triphasic formulation (16 % versus 10% of women). Altogether 9 % of the women on each pill discontinued treatment for medical reasons, the most common of which was spotting.

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