By Kenneth A. Foon (auth.), Kenneth A. Foon M.D., Hyman B. Muss M.D. (eds.)

This quantity, organic and Hormonal cures of melanoma, that is a part of the sequence melanoma remedy and study, provides chosen new info touching on biologic and hormonal remedy of melanoma. we now have tried to supply the reader with themes of significant curiosity rapidly. there's renewed curiosity in biologic remedy of melanoma. chapters assessment the function of interferon within the hematologic malignancies and in stable tumors. Vaccine cures have come to the vanguard of melanoma treatment re­ cently, and chapters technique assorted recommendations of vaccine cures; one studies the mobile vaccine treatments and one other the anti-idiotype ap­ proach. The hormonal treatment chapters concentrate on present makes use of of endocrine treatment in endometrial, breast, and prostate melanoma. additionally, hormonal options for the prevention of breast melanoma and endometrial melanoma, together with excit­ ing info when it comes to phytochemicals, are offered. the results of tamoxifen on endometrium is a subject of significant curiosity and is mentioned intimately. eventually, there's a bankruptcy on estrogen receptor expression and regula­ tion in human breast melanoma. those chapters are all written via specialists within the box and include well timed and appropriate info of curiosity to laboratory and medical scientists and practitioners alike. Biologic and endocrine remedies symbolize significant parts of melanoma examine curiosity. the appearance of more recent biologic treatments, together with new antibody­ exact remedies, and using biologics as tumor modulators to augment the consequences of alternative remedy regimens is an exploding street of research.

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Scheithauer W, Pfeffel F, Kornek 0, et al. 1992. A phase II trial of 5-fluorouracil, leucovorin and recombinant alfa-2b interferon in advanced adenocarcinoma of the pancreas. Cancer 70:1864-1866. Cascinu S, Fedeli A, Fedeli SL, et al. 1993. 5-fluorouracil, leucovorin and interferon alpha-2b in advanced pancreatic cancer: a pilot study. Ann Oncol 4:83-84. Lai CL, Lau lY, Wu PC, et al. 1993. Recombinant interferon-alpha in inoperable hepatocellular carcinoma: a randomized controlled trial. Hepatology 17:389-394.

1993. CHOP-bleo plus interferon for stage IV low-grade lymphoma. Ann Oncol 4:205-211. 141. Hagenbeek A, Carde P, Somers R, et al. 1992. Maintenance of remission with human recombinant alpha-2 interferon (Roferon-A) in patients with stages III and IV low-grade malignant non-Hodgkin's lymphoma: results from a prospective, randomized phase III clinical trial in 331 patients. Blood 80:288A. 142. Bunn PA, Foon KA, Inde DC, et al. 1984. Recombinant leukocyte A interferon: an active agent in advanced cutaneous T-cell lymphomas.

Fluorouracil and interferon-alpha, phase III [29]. Table 6. Fluorouracil in advanced colorectal cancer: cost Method Cost without drug charges Cost with drug charges Protracted infusion FUra and LV FUra and IFN $1344 $1064 $490 $1408 $1124 $1930 of colorectal cancer, including, specifically, fluorouracil and interferon-alpha, fluorouracil and either high-dose leucovorin or low-dose leucovorin, and protracted venous infusion of fluorouracil [30]. Results are shown in table 6. When charges other than drug costs were calculated, treatment with fluorouracil and interferon proved to be a very cost-effective therapy.

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