By Farshad Darvishi Harzevili

Due to its skill to degrade hydrophobic substrates hugely successfully, the non-conventional yeast Yarrowia lipolytica deals a number of purposes within the meals, feed, pharmaceutical, and advantageous chemistry industries, in addition to in environmental safeguard contexts akin to waste therapy and bioremediation.

The yeast breaks down hydrophobic substrates comparable to n-alkanes, fatty acids, fat, and oils, yielding important biotechnological items resembling natural acids, extracellular enzymes, aroma compounds, bioemulsifiers, polyols, single-cell proteins, and single-cell oils. extra, Y. lipolytica is a good platform for the creation of varied heterologous proteins; greater than 100 heterologous proteins – together with these of viruses, micro organism and fungi, in addition to plant, animal and human proteins – have already been produced in Y. lipolytica. considering that its genome has been sequenced, it's now attainable to exploit new recombinant expertise and metabolic engineering so one can enhance the metabolic pathways fascinated by the production of fascinating metabolites and products.

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Extra resources for Biotechnological Applications of the Yeast Yarrowia lipolytica

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Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005). 4 Succinic Acid Succinic acid and its derivatives are used as flavoring agents for food and beverages. This acid could be used as feedstock for dyes, insecticides, perfumes, lacquers, as well as in the manufacture of clothing, paint, links, and fibers (McKinlay et al. 2007). Succinic acid is widely used in medicine as an antistress, antihypoxic, and immunity-improving agent, in animal diets, and as a stimulator of plant growth.

Proteases production is also controlled by carbon, nitrogen, and sulfur starvation (Ogrydziak and Mortimer 1977). Both proteases are similarly induced at the end of the exponential phase on complex media containing proteins, whereas the type of protease synthesized is strictly dictated by ambient pH (Glover et al. 1997). Extracellular alkaline protease (AEP) and acid extracellular protease (AXP) are encoded by XPR2 and AXP1 genes, respectively. Induction of the AXP1 gene occurs at acidic pH which leads to secretion of an acid protease (Axp), whereas the XPR2 gene induce at neutral pH and an alkaline protease (Aep) is produced (Glover et al.

They have also become essential to the fine chemical industry because of the demand for singleisomer intermediates. The yeast Y. lipolytica is able to perform bioconversion of certain compounds including fatty acids, alkanes, steroids, and trinitrotoluene. Fatty acids resulting from the hydrolysis of lipids by lipases can be entered to different oxidation pathways: x-oxidation of fatty acids to a, x-dicarboxylic acids, and the degradative b-oxidation of fatty acids to CO2 and water. Alkanes are ultimately converted into fatty acids via a-oxidation pathway (See ‘‘Yarrowia lipolytica: An Overview,’’ in Sect.

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