By Joachim Krebs, Marek Michalak

Calcium is a flexible service of indications regulating many elements of mobile task similar to fertilization to create a brand new lifestyles and programmed cellphone loss of life to finish it. Calcium homeostasis is precisely managed through channels, pumps and exchangers functioning as gates for calcium access and unlock. provided that calcium is this type of flexible messenger the sphere of calcium signaling is always and quickly increasing. This booklet reports the newest advancements in calcium signaling via best specialists within the box. it's a cutting-edge precis of our current wisdom during this speedy growing to be box and gives perception into the extraordinary development made in lots of parts of calcium signaling, whereas reminding us of the way a lot is still discovered.

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The genetic defect of calpain X, another monomeric calpain that does not contain EF-hand Ca2+-binding motifs but could still be Ca2+ sensitive as it still contains the non-EF-hand Ca2+-binding sites, has been shown to be linked to the increased susceptibility to type 2 diabetes [42]. 4. Dysfunctions of neuronal Ca2+ sensor proteins These proteins (NCS) are expressed in the central nervous system and in retinal photo­ receptors [43]. They all possess four EF-hand Ca2+-binding motifs (some of which may be not operational) and, as a rule, are N-terminally myrystoylated.

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