By Georges Mathé MD (auth.)

I want to thank all my co-workers who've collaborated with me, from 1963 previously, in organic and medical examine within the box of melanoma energetic immunotherapy, of its immuno­ prevention and immunorestoration. they're going to usually be quoted during this ebook. i'm relatively thankful to people who have helped me to write down it via reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her prepared and effective co-operation within the preperation of the manuscript. i'm eventually thankful to all authors of books or articles who approved me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. creation and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour relating melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and cellphone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen­ tiation 22 2. 2. three. T-Lymphocyte features 25 2. 2. four. B-Lymphocyte capabilities 30 2. 2. five. Macrophage capabilities 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms inquisitive about Tumour cellphone Rejec­ tion 33 2. three. 1. 1. In vivo facts for Tumour Immunity 33 2. three. 1. 2.

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16). The infiltration of Burkitt's (African) lymphosarcoma by many macrophages (Fig. , 1975a; MAT~ and RAPPAPORT, 1976). , 1973), myelomonocytic leukaemia and lymphosarcomas (CLINE , 1973) , but correlation between depressed macrophage function and de fective antineoplastic "defence" has not been c learly established. Macrophage c ontent of experimental tumours was shown to vary from one neoplasia to another . Tumours with many resident macrophages are less likely to metastasize than those with few (BIRKBECK and CARTER, 1972; ECCLES and ALEXANDER, 1974).

Antibody bound specifically to target cells can induce cytotoxicity by activating non-immune effector cells, the K-cells. 5. V. , 1973a; BANSAL and SJOGREN, 1973) Cell-mediated cytotoxicity a Cytotoxic antibodies Blocking serum factors Progressive tumour growth + After complete tumour excision + + After tumour recurrence + ? + After immunization + + ! Unblocking serum factors + + + a Microcytotoxicity assay cellular cytotoxicity assays. K-cells appear as fully capable effector cells in the microcytotoxicity assay and probably in the colony-inhibition test.

T-Zymphoeytes occupy predominantly paracortical regions of lymph nodes and periarteriolar zones of the splenic white pulp, which are consequently referred to as thymus T-dependent areas (Figs. 10). They are depleted after neonatal thymectomy and in Di George's disease (MILLER, 1962; Di GEORGE, 1968). , 1966; TURK and OORT, 1967). These B-dependent areas (Figs. 10) are depleted after bursectomy in avians and in children with agammaglobulinaemia (BRUTON, 1952). , 1970). Little is known about the development of stem cells to immunocompetent B-Iymphocytes.

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