By Antonella Surbone, Fedro Peccatori, Nicholas Pavlidis (auth.)

Te eu college of Oncology is extremely joyful to ber of woman former melanoma sufferers anticipated to determine that the college of its path on melanoma and feature a winning being pregnant. being pregnant has succeeded—and in a remarkably one other staff of people that merits brief time—in generating this tremendously stimulat - our awareness are ladies who've survived a ing booklet. adolescence melanoma and who will be controlled only a few human and scientific occasions en - via a multidisciplinary expert crew. fortress- compass such contrary extremes as being pregnant nately, many stories are underway and we are hoping and melanoma, desire and worry, occasionally existence and to quickly have new insights into this extraord- demise. narily advanced factor. Any doctor who has been con- Te ecu college of Oncology is thankful fronted with this factor is aware how difcult it really is to Dr. A. Surbone for her profitable coordin -a from the scientific point of view but additionally how chal- tion of our educating direction and for having taken lenging it's at the emotional part. the initiative to post this publication. we are hoping that during contemporary years the good fortune of melanoma medication it's going to give a contribution to assisting many young ones have has elevated the variety of survivors and the their mom cured of her melanoma and be ready to size in their survival, therefore expanding the num- love them forever.

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It seems possible that genetic predisposition may explain the differing susceptibility to teratogenicity among patients given the same drugs. The potential teratogenic effect of any chemotherapeutic agent used during pregnancy depends on the total dose and on the fetal developmental stage at the time of exposure. Chemotherapy during the first trimester may 22 increase the risk of spontaneous abortions, fetal death, and major malformations (Leslie et al. 2005; Zemlickis et al. 1992). Malformations reflect the gestational age at exposure, and the fetus is extremely vulnerable during weeks 2–8, at which organogenesis occurs (Cardonick and Iacobucci 2004; Weisz et al.

Caution is therefore warranted before new agents are administered to pregnant women, even if other drugs from the same class are considered safe. Recently there has been an increasing interest in the development and use of different biological anticancer therapies, the most popular being bevacizumab (Avastin) and cetuximab (Erbitux), which are used most commonly in metastatic colorectal cancer. The fact that bevacizumab is an antiangiogenic factor suggests that it may be associated with severe adverse effects during pregnancy.

6 This novel tyrosine kinase inhibitor has a major role in the treatment of chronic myeloid leukemia (CML) and of gastrointestinal stromal tumors (GIST). 5). However, animal models suggest that this agent may be teratogenic. Therefore, at this time, imatinib cannot be recommended for treating pregnant patients. This is a monoclonal antibody that blocks the human epidermal growth factor receptor 2 protein and is administered to patients with breast cancer. Currently there are only two reports of treatment with trastuzumab during pregnancy.

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