By Ivan Damjanov MD, PhD (auth.), Ivan Damjanov MD, PhD, Fang Fan MD, PhD (eds.)

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Thymic carcinoma: spectrum of differentiation and histologic types. Pathology. 1998;30:111–122. 7 Tumors of the Digestive System Grace Guzman and Gregorio Chejfec Introduction The tumors of the tubular part of the digestive system, the liver, and the pancreas account for a significant portion of the day-to-day surgical pathology material in most diagnostic pathology laboratories. While many of these gastrointestinal tumors are microscopically identical to the homonymous tumors in other parts of the body, some are unique to the digestive system.

2. , 2004). “Severe dysplasia” is the preferred term for the lesions that were previous called intraepithelial adenocarcinoma or carcinoma in situ. 3. Dysplasia is a precursor of adenocarcinomas that develop in ulcerative colitis and Crohn disease. The biopsy findings in patients with chronic inflammatory bowel disease are reported as follows: • Negative for dysplasia. Special attention should be paid to the surface epithelium, which in these cases shows normal maturation. One should ignore the regeneration-related changes in the basal parts of the crypts, which may resemble adenomatous epithelium.

Well, moderately, or poorly differentiated carcinoma). • Clear cell carcinoma (Figure 6-6) • Basaloid carcinoma (Figure 6-7) • Adenosquamous carcinoma • Small cell neuroendocrine carcinoma • Sarcomatoid carcinoma • Anaplastic carcinoma Poorly Differentiated Thymic Epithelial Neoplasm (Thymic Carcinoma) This tumors is defined as having lost the characteristic organotypical features of the thymus and by displaying overt cytologic evidence of malignancy. Thymic carcinoma can display a wide variety of microscopic appearances and may closely resemble carcinomas of other organs (5).

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