By Sheldon A. Weiner (auth.), Earl A. Surwit M.D., David S. Alberts M.D. (eds.)

Cytological screening for the id of intraepithelial neoplasia of the cervix as a precursor lesion for cervical melanoma has been good proven as an efficient capacity for lowering the occurrence of invasive carcinoma. regardless of those screening efforts, carcinoma of the cervix is still one of many extra universal malignancies in ladies and it's the major reason behind melanoma dying in lots of nations within the western hemisphere. it really is anticipated that during 1986 there'll nonetheless be 14,000 new situations of invasive melanoma, with 6,800 deaths within the usa on my own. regrettably, a lot of those sufferers current with complex ailment, posing tough administration difficulties for the clinician accountable for their care. The remedy of early level invasive carcinoma of the cervix (lesions limited to the cervix and vagina) continues to be both radical surgical procedure, radical radiation treatment or a mixture thereof This procedure is awfully potent within the overwhelming majority of sufferers. although, there is still a subset of sufferers with early level affliction which are at excessive threat for recurrence. Dr Kjorstad (Chapter 2) has pointed out adenocarcinomas and adenosqua­ mous carcinomas as having a very negative diagnosis. moreover, sufferers with greater than 3 optimistic lymph nodes or with involvement of lymph nodes outdoor of the pelvis have a truly terrible diagnosis. He has iden­ tified the CEA as a possibly predictive marker for those sufferers with negative diagnosis, particularly in sufferers with adenocarcinomas.

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1949. The lymphatic spread of carcinoma of the cervix and of the body of the uterus. Am J Obstet Gynecol 58: 924. 15. Morrow CPo 1980. Is pelvic radiation beneficial in the postoperative management of Stage IB carcinoma of the cervix with pelvic node metastasis treated by radical hysterectomy and pelvic lymphadenectomy? Gynecol Oncol 10: 105. 30 16. Iversen T, Kjorstad KE, Martimbeau PW. 1982. Treatment results in carcinoma of the cervix stage IB in a total population. Gynecol Oncol 14: 1. 17. Kjorstad KE, Martimbeau P, Iversen T.

One of the main problems when working with the clinical relevance of CEA is the reproducibility of the test in the laboratory. The most commonly applied test, the CEA-Roche test of Hansen [38], uses perchloric acid (PCA) extraction followed by dialysis or gel filtration to remove PCA prior to the radioimmunoassay. Performed as recommended the test is sensitive and specific. The extraction and purification procedures are time consuming and delicate and will definitely influence the reproducibility in large scale routine.

1962. Carcinoma of the uterine cervix. Incidence and influence of age. Acta Radiol (Suppl) 92. 3. Kottmeier HL. 1964. Surgical and radiation treatment of carcinoma of the uterine cervix. Acta Obstet Gynecol Scand (Suppl) 43. 4. Gynning I, Johnsson JE, Aim P, Trope C. 1983. Age and prognosis in Stage IB squamous cell carcinoma of the uterine cervix. Gynecol Oncol 15: 18. 5. Kjorstad KE 1977. Carcinoma of the cervix in the young patient. Obstet Gynecol 50: 28. 6. Kjorstad KE. 1977. Adenocarcinoma of the uterine cervix.

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