By Jean-Marie Lachapelle (auth.), Jeanne Duus Johansen, Peter J. Frosch, Jean-Pierre Lepoittevin (eds.)

The 5th variation of touch Dermatitis covers intimately each a possibility point of irritant and allergic touch dermatitis and its modern day administration. targeted emphasis is given to immunological mechanisms, molecular facets of sensitizers, peculiar scientific varieties, reactions to medicaments, and occupational and environmental components. for you to optimize the diagnostic strategy, quite a lot of info is supplied, together with a dictionary of touch allergens. Retained chapters from the former version were completely revised to mirror the newest wisdom. moreover, thoroughly new chapters were extra on various themes, together with genetics, the position of the surface barrier, the hyperlink among breathing signs brought on by way of chemical substances and speak to dermatitis, and prevention. The editors and authors are all major practitioners within the box. the great yet approachable textual content is supplemented by means of loads of complete colour illustrations and tables. middle messages spotlight crucial details and should aid the reader to achieve a greater knowing of the topic and larger competence in daily practice.

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It is related to ACD, AD, and other inflammatory diseases [244, 249, 250]. The higher ­frequency of the TNF-a – 308 A variant in AD also contributes to the explanation of the enhanced irritant reactivity in AD. A SNP at position – 238 in the promoter region of the TNF-a gene does not seem to increase the risk of ICD [244]. A SNP (C/T substitution) in the interleukin-1a (IL-1a) gene at position – 889 in the promoter region is not associated with ICD, but seems to be protective of hand dermatitis in apprentices in training for highrisk occupations for ICD [244].

Measures were performed in macroscopically unaffected skin. Patients with AD also have a higher penetration rate of SLS in uninvolved skin compared with nonatopics [187, 211], especially those with active AD lesions. Patients with inactive dermatitis showed intermediate values in skin diffusibility [211]. The baseline level of TEWL does not seem to be correlated with skin thickness in patients with AD, which indicate that other factors than skin thickness play a role in permeability of the skin in AD [211].

The basal barrier function did not, however, differentiate between eczema patients and controls [199]. In contrast, patients with irritant contact dermatitis taken together as a whole did not show an increased response to acute irritant assault compared with healthy controls, whereas patients with seborrhoiec dermatitis did A. C. Carlsen [237]. Patients with seborrhoiec dermatitis have higher levels of the important proinflammatory cytokine IL-a in the skin [238]. Cancer lowers the reaction to irritants [239].

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