By John Ziebuhr (Eds.)

Coronaviruses, the newest quantity within the Advances in Virus Research sequence first released in 1953, covers a various diversity of in-depth experiences, offering a helpful evaluation of the sphere. This sequence is a important source for virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers.

  • Contains contributions from best specialists in virus research
  • Provides accomplished stories for normal and professional use
  • Presents the 1st and longest-running assessment sequence in virology

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Extra resources for Coronaviruses

Sample text

Blue boxes indicate the N-terminal regions in alpha- and betacoronavirus spike proteins, which were mapped based on sequence homology between viruses within the same genus. Green boxes indicate known receptor-binding domains in the C-terminal region of S1. Known receptors are indicated in the boxes: APN, aminopeptidase N; ACE2, angiotensin-converting enzyme 2; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid; DPP4, dipeptidyl peptidase-4.

2003, 2004), enabling the close apposition and subsequent fusion of the viral and host lipid bilayers. 5. TROPISM CHANGES ASSOCIATED WITH S PROTEIN MUTATIONS Changes in the S protein may result in an altered host, tissue, or cellular tropism of the virus. This is clearly exemplified by genomic recombination events that result in exchange of (part of ) the S protein and in a concomitant change in tropism. , 2000). To this end, interspecies chimeric coronaviruses were generated, which carried the spike ectodomain of another CoV and which could be selected based on their altered requirement for an entry receptor.

Biochemistry 46 (22), 6488–6499. 1021/bi062057p. , 2009. Role of spike protein endodomains in regulating coronavirus entry. J. Biol. Chem. 284 (47), 32725–32734. 1074/jbc. 043547. , 2011. A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. J. Virol. 85 (2), 873–882. 02062-10. , 1981. Coronavirus JHM: a virion-associated protein kinase. J. Gen. Virol. 52 (Pt. 2), 235–243. 1099/0022-131752-2-235. , 2005. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

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