By Mario E. Lacouture

This is often the 1st e-book to target widespread and often disabling unintended effects regarding the surface, hair, and nails in melanoma sufferers. It offers distinctive descriptions of mechanism-of-action in all present oncology medications and the medical presentation and mechanisms underlying their dermatologic unwanted effects, along rigorously offered therapy ideas, permitting physicians to noticeably increase their care of sufferers with melanoma. while latest oncology and dermatology textbooks merely in short take care of this subject, this source bargains dermatologists and different practitioners a concentrated standpoint on cancer-related dermis stipulations.

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Extra resources for Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

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Unless they become secondarily infected, erosions do not scar. 8 Purple plaques and nodules on the hands. Kaposi sarcoma. Photograph © Amit Garg. 9 A warm tender fluctuant red erythematous nodule on the buttock. An abscess in a patient receiving chemotherapy. 10 Red erythematous ulcers forming scalloped borders (demonstrating grouping) in the perineum. Herpes simplex virus infection in an immunocompromised cancer patient. 29 Section 1 Dermatology and Oncology palpation, on which the skin may feel board-like and bound down.

The bottom of the hair root is known as the hair matrix. The hair matrix cells divide and move up the follicle, differentiating into either hair cells or inner epithelial sheath cells (hair lining). Interspersed amongst matrix stem cells are melanocytes, which produce hair pigment. The pigment is synthesized from the amino acid tyrosine (catalyzed by the enzyme phenol-oxidase) and transformed to dopa and then to dopaquinone. Further transformation of dopaquinone proceeds in two directions: either directly to indolquinone or through the addition of the amino acid cysteine.

Immigrant cells of the epidermis include melanocytes, Langerhans cells and Merkel cells. Melanocytes are neural crestderived dendritic cells largely residing in the basal layer of the epidermis. These cells synthesize pigment and are primarily responsible for imparting color to the skin. Langerhans cells are the marrow derived dendritic antigen presenting cells of the epidermis whose cytoplasm contains characteristic racket-shaped structures known as Birbeck granules. Tumor antigens presented by Langerhans cells mount a tumor-specific immune response and, as such, these cells have been evaluated as vehicles of antitumor and vaccine therapies.

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