By Fred E. Hahn (auth.), Prof. Dr. Jürgen Drews, Prof. Fred E. Hahn Ph. D. (eds.)

The proposal of chemotherapy as originated by way of Paul Ehrlich relies at the premise that antiparasitic medicines should have homes: they have to first bind to precise buildings of the parasite which Ehrlich known as chemoreceptors. next to their attachment to the chemoreceptor and by way of advantage of this binding they need to own the potential to kill the parasite. because the host that's to be cured of an invading parasite additionally encompasses a huge variety of chemoreceptors, that experience the aptitude to bind poisonous compounds, the duty of the chemo­ therapist is to spot chemoreceptors of the parasite that are . no longer represented within the host and to layout medicines which bind selectively to them~ during this context, Ehrlich known as· for "the entire and exhaustive wisdom of the entire varied chemoreceptors of a undeniable parasite" as a "sine qua non for fulfillment in chemotherapy". mockingly and even if chemotherapy has turn into a truly complicated and profitable healing self-discipline, few of its tri­ umphs were accomplished by means of following Ehrlich's unique precepts. to the contrary, within the vast majority of instances, powerful medications were came across with none wisdom in their chemoreceptors, and those medicinal drugs themselves have conversely been used as instruments to check the character of the chemoreceptors concerned. In different phrases: chemother­ apy, significantly antibacterial chemotherapy, has been profitable with no ever residing as much as the elemental criteria recommend by means of Paul Ehr­ lich.

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Additional resources for Drug Receptor Interactions in Antimicrobial Chemotherapy: Symposium, Vienna, September 4–6, 1974

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Reference. Dependent variable name. Independent variable names. COMPOUND DATA 1. 2. 3. 4. S. Biological activity. ) Compound name & WLN Deviation from regression. WLN screen. EQUATION DATA 1. 2. 3. 4. 5. Regression equation. Correlation coeff. (R). Standard deviation. Confidence intervals etc. Optimal P value (if any). Fig. 1. , topological (in Wiswesser Line Notation); and numeric. Searching the file will, at times, use Boolean and/or logic with combinations of all three types of information. With certain modifications, ordinary PL/I is suitable.

2. System Numbers The variable structure of each of the compounds tested appears in the usual chemical notation along with the cannonical WLN for the entire compound for exact structure verification. The parameters in this study are: partition coefficient, Taft's electronic sigma star, and molar refractivity. The activities, observed and calculated, are in terms of log llc and the deviations between the two are listed. An asterisk can be used to prevent an 'outlier' from influencing the regression line, but one can still keep track of its activity and the extent of its deviation.

0 Isl ~mol/l Fig. S. Determination of the inhibitory activity of 2-bromo-4-nitroNLphenylsulfanilamide by the kinetic method. , 1972). are used instead of the i50 values (which are identical for less active sulfanilamides) the correlation between the log of biological activity and the physicochemical parameters becomes more significant (Fig. 9). A likely reason for such behaviour is depletion of the inhibitor, presumably due to its utilization as a false substrate. In addition to other indirect evidence for the formation of a sulfanilamide-containing folate analogue in the cell-free experiments, Brown (1962) has already shown that sulfanilic acid is incorporated by E.

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