By Wolfgang J. Köstler, Yosef Yarden (auth.), Maria Sibilia, Christoph C. Zielinski, Rupert Bartsch, Thomas W. Grunt (eds.)

Growth issue receptors have lengthy been recognized to force malignant transformation and melanoma development. The epidermal progress issue receptor (EGFR, ErbB, HER) process is probably going the easiest defined membrane receptor tyrosine kinase relatives in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the remedy of HER-2-positive complex metastatic breast melanoma, a brand new period has dawned within the remedy of this malignant disorder. regrettably, trastuzumab-sensitive cancers continuously improve resistance to the antibody after a while. fresh scientific reviews have published that those refractory tumors are nonetheless attentive to inhibition of the HER receptor relatives utilizing twin HER-1/-2 inhibitors akin to lapatinib (Tykerb/Tyverb). furthermore, a multiplicity of novel, stronger irreversibly appearing small molecular HER tyrosine kinase inhibitors are within the pipeline of many drug constructing businesses and are being evaluated within the medical setting.

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Extra info for Drugs for HER-2-positive Breast Cancer

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Zwang Y, Yarden Y (2009) Systems biology of growth factor-induced receptor endocytosis. Traffic 10:349–363 140. Levkowitz G, Waterman H, Zamir E, Kam Z, Oved S, Langdon WY, Beguinot L, Geiger B, Yarden Y (1998) c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 12:3663–3674 141. Wang Y, Du D, Fang L, Yang G, Zhang C, Zeng R, Ullrich A, Lottspeich F, Chen Z (2006) Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.

Proc Natl Acad Sci USA 88:10435–10439 120. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431–442 121. Daly RJ, Binder MD, Sutherland RL (1994) Overexpression of the Grb2 gene in human breast cancer cell lines. Oncogene 9:2723–2727 122. Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H (2006) A role for the scaffolding adapter GAB2 in breast cancer.

Proc Natl Acad Sci USA 106:2835–2840 130. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A et al (2008) An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 68:6084–6091 131. Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmstrom PO, Mansukhani M, Enoksson J et al (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.

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