By John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes

This article reports the newest rules in tumor biology, explains the pharmacologic foundation of the brokers used, and discusses how they're utilized in scientific perform. half One offers an summary of the medical significance of endocrine remedy, and describes the functions of the imperative sessions of gear, together with antiestrogens, aromatase inhibitors, progestins, and progesterone receptor antagonists. This part additionally discusses ovarian ablation. half bargains with the organic facets of endocrine remedies, and relates present realizing of tumor biology and the pharmacologic foundation of hormonal brokers to their scientific functions. one of the subject matters lined are resistance and sensitivity to treatment. half 3 outlines destiny suggestions, specifically using mixture endocrine treatment, adjuvant development issue treatment and using anti-invasive brokers. this article is key for oncologists and pharmacologists alike.

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Ludwig Breast Cancer Study Group. Chemotherapy with or without oophorectomy in high risk premenopausal patients with operable breast cancer. J Clin Oncol 1985; 13: 1059–67. Kaufmann M, Jonat W, Blamey R, Schumacher M. The Zebra Study: Zoladex (Goserelin) versus CMF as adjuvant therapy in the management of node positive stage II breast cancer in pre/perimenopausal women aged 50 years or less. Proc Am Soc Clin Oncol 1998; 17: 151a (Abs 577). Jonat W. Zoladex versus CMF adjuvant therapy in pre/peri-menopausal breast cancer: Tolerability and amenorrhea comparisons.

42. Davidson N, O’Neill A, Vukov A et al. Effect of chemohormonal therapy in premenopausal, node (ϩ), receptor (ϩ) breast cancer: an Eastern Cooperative Oncology Group phase III intergroup trial (E5188, INT-0101). Proc Am Soc Clin Oncol 1999; 18: 67a. 43. Howell A, George WD, Crowther D et al. Controlled trial of adjuvant chemotherapy with cyclophosphamide, methotrexate and fluorouracil for breast cancer. Lancet 1984; ii: 307–11. 44. Pourquier H. The results of adjuvant chemotherapy are predominantly caused by the hormonal changes such therapy induces: In: Medical Oncology.

ENDOCRINE THERAPY OF BREAST CANCER and endocrine therapy alone or in combination in premenopausal patients (GABG Trial 1). Rec Results Cancer Res 1989; 115: 118–25. Kaufmann M, Jonat W, Kleeberg UR. Goserelin, a depot gonadotropin-releasing hormone agonist in the treatment of premenopausal patients with metastatic breast cancer. J Clin Oncol 1989; 7: 1113–19. Kaufmann M, Jonat W, Schachner-Wunschmann E. The depot GnRH analogue goserelin in the treatment of premenopausal patients with metastatic breast cancer – a 5 year experience and further endocrine therapies.

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