By Susan T. Nedorost

Management of Generalized Dermatitis in scientific Practice interprets the mechanisms of dermatitis from uncomplicated technology facts to perform established strategies for medical care. The function of allergic touch dermatitis in atopic dermatitis is explored intensive. fundamental care physicians, allergists, and dermatologists will benefit from the clean viewpoint that strikes past therapy with corticosteroids and gives diagnostic and healing algorithms for this advanced condition.

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Generalized Dermatitis in Clinical Practice

Administration of Generalized Dermatitis in scientific perform interprets the mechanisms of dermatitis from uncomplicated technology proof to perform dependent strategies for scientific care. The function of allergic touch dermatitis in atopic dermatitis is explored intensive. basic care physicians, allergists, and dermatologists will benefit from the clean standpoint that strikes past remedy with corticosteroids and gives diagnostic and healing algorithms for this advanced .

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Stasis dermatitis), infection, or from environmental chemicals. Many allergens are also irritants: dust mites contain proteases that decrease barrier function and are countered by endogenous protease inhibitors [1]. The innate immune system senses irritants and differentially instructs the adaptive immune system such that irritants have an effect on allergic response [2]. 22 Chapter 3. The Role of Irritation in Dermatitis Emollients Irritant dermatitis can be subdued by application of emollients that restore epidermal barrier function.

6%. In our inter-disciplinary eczema clinic (see Chap. 10), we speculate that this is due to ingestion of soft peanut snacks by Israeli infants that can be inserted into the mouth without skin contact. Peanut butter, on the other hand, is quite likely to stick to the perioral skin. In this sense, food allergy can be considered systemic contact allergy with sensitization via inflamed perioral skin (Fig. 2). 2 Soft peanut snacks that babies can dissolve in their mouths In support of this model of food sensitization, a large German study showed no protective effect for atopic dermatitis or food sensitization (defined by tests for immediate hypersensitivity) of delayed introduction of solid foods beyond 4–6 months of age [7].

1007/978-1-4471-2897-7_4, © Springer-Verlag London 2012 29 30 Chapter 4. 1 Perioral inflammation in an infant. Drooling provokes irritant dermatitis which increases risk for allergic sensitization Impaired barrier function also allows for penetration of large molecules such as antigenic food proteins. If food proteins are first encountered on inflamed skin, rather than on mucosal surfaces with absent co-stimulatory molecules, then food allergy rather than tolerance may result [4, 5]. Filaggrin deficiency has been shown to increase the risk of peanut allergy [6].

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