By Eve Van Cauter (auth.), E. van Cauter Ph. D., G. Copinschi M.D., Ph. D. (eds.)

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J Clin 1973 10. , R Leclercq, J Golstein, C Robyn, D Desir" MH Delaet, E Virasoro, L Vanhaelst, M L'Hermite, and E Van Cauter, Seasonal modifications of circadian and ultradian variations of ACTH, cortisol, S-MSH, hPRL and TSH in normal man. Chronobiologia 4:A106, 1977 (Abstract) 11. ), Vol. II, New York, Grline and Stratton, p. 2079, 1979 2S 12. S. Government Printing Office, 1972 13. Weitzman, ED, D Fukushima, C Nogeire, H Roffwarg, TF Gallagher and L Hellman, Twenty-four pattern of the episodic secretion of cortisol in normal subjects.

5 . \ ! 0. ... E .... 4 c . 7 CJ " CL OCK HOUR £LAPSED "IMUIES I5 , .. AE ENTRAINED Figure 1. IS 2110 15 2••0 TIME .... ,. 15 Secretory pattern of growth hormone and cortisol in one subject (AE) during 4 days of entra inment. .. 15 " 33 Examination of the individual cortisol plasma concentration time series revealed that on many non-scheduled (free-running) biological days, cortisol was secreted just prior to sleep onset and then would stop being secreted for several hours after sleep onset; a pattern not seen during entrainment (Figs 1,2).

W~M taQ~n ~t~~p No ~t~~p; Table 1. tuA~. Folt ~~iM eomp~on, the. tio~ wMe. pMUy tM~ 60~~d into the. table.. 6 SWS Ref. 6 Ref. 7 Ref. 6 present series On experimental days, frequent blood sampling was an additional factor which might have disturbed the animals. this constitute an acute stress? Did When blood samples were taken during the day and during the night, the animals often became aware of the procedure. During the day, light 49 napping was often disturbed by the sampling, but, during more profound naps, the taking of a blood sample would often go unnoticed by the animal.

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