By Hiromi Sato, Satoshi Matsumoto (auth.), Satoshi Matsumoto M.D., Norihiko Tamaki M.D. (eds.)

During the prior ten years, expertise has been progressing at a swift speed within the box of scientific technological know-how, and there were nice advancements within the simple realizing, analysis, and therapy of hydrocephalus. the current quantity includes the complaints of the overseas Symposium on "Hydrocephalus" that used to be held in Kobe, Japan, from November 12-14, 1990. the aim of the symposium was once to focus on the new advances during this box and to supply a special chance for trade of easy and medical wisdom between specialists during this box. in the course of the symposium, eighty four papers have been awarded by means of 240 participants from 14 international locations. This quantity is a compre­ hensive description of the present wisdom during this quarter, and it may well support to outline what's identified and to discover new techniques to appreciate the patho­ genesis, pathophysiology, prognosis, and therapy of the hydrocephalic method. The editors take nice excitement in expressing their due to the individuals for his or her participation and cooperation, and to Springer Verlag for private and technical suggestions in publishing the court cases. We clearly desire that this quantity will give a contribution to bettering the deal with­ ment for hydrocephalus. August 1991 The Editors V Contents Preface.......................................................... V record of participants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . XV . . . . . . . . . . . . . specified Exhibition 1 Hydrocephalus: ancient evaluate H. Sato and S. Matsumoto. . . . . . . . . . . . . . . . . . . . . . . . . . . three . . . . . . . . . . .

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These findings show that there are interesting similarities between this model and the Dandy-Walker syndrome; the findings indicate that the cause of the Dandy-Walker syndrome is not limited to malfunction in the vicinity of the fourth ventricle, but is due to general systemic metabolic errors, 34 H. Yamada et al. such as niacin deficit in fetal life, as described above. The anomalies seen around the fourth ventricle in the Dandy-Walker syndrome may be one of the features of the systemic disease.

9) Discussion In earlier studies, large animals such as cats and rabbits, in which aquired hydrocephalus was induced by such techniques as intracisternal injection of kaolin, were used as hydrocephalic animal models for experimental shunt oper- 20 K. Suda et al. ~ sham·operated group (n=ll) • early shunt group (n=12) }s Apical dendrites }s Basal dendrites 10 20 spine density (f 20,um) 30 40 Fig. 6. Comparison of the spine density of apical and basal dendrites of pyramidal neurons between early and sham-operated groups in layers II and III of the frontoparietal cortex.

The present model showed cystic enlargement of the fourth ventricle and many CNS anomalies, such as absence of the corpus callosum, cerebellar hypoplasia, maldevelopment of the choroid plexus, and so on, which are associated with hydrocephalus. These findings show that there are interesting similarities between this model and the Dandy-Walker syndrome; the findings indicate that the cause of the Dandy-Walker syndrome is not limited to malfunction in the vicinity of the fourth ventricle, but is due to general systemic metabolic errors, 34 H.

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