By Hans-Peter Meyer, Diego Schmidhalter

The submersed cultivation of organisms in sterile containments or fermenters has develop into the traditional production approach, and may stay the most effective for a while to return. This booklet hence addresses submersed telephone tradition and fermentation and its significance for the producing undefined. It is going past expression platforms and integrally investigates all these elements proper for production utilizing suspension cultures. In so doing, the contributions hide all business cultivation equipment in a finished and comparative demeanour, with lots of the authors coming from the itself. looking on the adulthood of the know-how, the chapters deal with in flip the expression process, easy method layout, key components affecting procedure economics, plant and bioreactor layout, and regulatory aspects.

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The general consensus is that we have cultured less than 1% of bacteria as monoseptic suspension cultures. Besides microorganisms, there are several other cells and organisms that are not used for production but are known to be able to grow in some form of suspension culture, while others have never been reported to be grown in suspension culture but theoretically could be. The cultivation in cell factories of macroalgae, microalgae diatoms, and cyanobacteria in open ponds, closed photo-bioreactors, or closed fermenters are areas of interest [31] not only because of their recognized commercial potential, but also because of their theoretically relative ease of use in bioreactors, which provide better control over monocultures.

Rossel-Uclaf (vitamin and steroids) and Schering Berlin (now Bayer) are other companies active in the biotechnological production of steroids. Today, semisynthetic processes using biocatalytic or enzymatic steps are used beyond steroids. Small molecule blockbusters, for example, atorvastatin (Lipitor) or sitgagliptin (Januvia), use semisynthetic synthesis, with biocatalysis as an important tool in the fine chemical synthesis toolbox [9]. 4 Antibiotics, a US-Lead Turning Point in Fermentation Technology The biggest impact on biotechnology, however, came from antibiotics because of the medical need and the urgency to have a large-scale production process at hand.

In the following year the Canadians provided engineering know-how and trained numerous qualified experts from applicant countries [13]. The Americans, British, French, and Soviets had large troop contingents in Germany and Austria, and penicillin supplies were essential for their health. To assure this supply Hoechst was assisted in opening a penicillin production plant close to Frankfurt under a program of the US Marshall Plan. The company had one advantage over the companies from countries sponsored by the UNRRA program: Germany received the latest US fermentation technology know-how as well as highly productive strains from Bristol-Myers.

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