By Thomas Merigan (Eds.)

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Agents Chemother. 2 4 76. T a n , Υ. H. & B e r t h o l d , W . ; ; (1977) J. G e n . V i r o l . 34_ 4 0 1 . , De M a e y e r , E . & M o n t a g n i e r , L. ; (19 72) P r o c . N a t l . A c a d . S c i . USA £9 1 2 0 3 . A b r e u , S. , B a n c r o f t , F. C. & S t e w a r t I I , W . E . ; (1979) J. B i o l . Chem. 2 5 £ 4 1 1 4 . REGULATION OF THE HUMAN INTERFERON β GENE IN MOUSE L CELL CLONES AND IN HUMAN CELLS John Collins, Hansjorg Hauser, Gerhard Gross, Wolfgang Bruns, Heinz-Kurt Hochkeppel and Ulrich Mayr Genetics Department, Gesellschaft fur Biotechnologische Forschung mbH (GBF), Mascheroder Weg 1 D-3300 Braunschweig-Stockheim, F.

Enz. 6 8 , 152-176. , Hochkeppel, Η. K. and Mayr, U. (1982). Nature (submitted). Graves, Η. E . and Meager, A. (1980). J. Gen. Virol. 4 7 , 489-495. , Chudzio, T. and Stewart, W. E . (1977). J. Gen. Virol. 37, 221-223. Hochkeppel, Η. , Menge, U. and Collins, J. (1981). Eur. J. Biochem. 118, 4 3 7 - 4 4 2 ) . Berk, A. J. and Sharp, P. A. (1977). Cell 12, 721-732. 40 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. J O H N C O L L I N S et al. Weaver, R. F. and Weissmann, Ch. (1979).

We have analysed the induction of human IFNB and interferonassociated genes in human fibroblast and lymphoblastoid cells (8, 9) and in mouse fibroblast clones. We have previously r e ­ ported the isolation and physical characterisation of a 36 kilobases region of the human genome including and surrounding an intact I F N 6 gene (10). The discovery that other p o l y ( r l ) : poly(rC) inducible genes are located in this cloned region presented the possibility that regulatory functions were acting through a common pathway on this family of genes.

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