By Jerome Z. Litt, Neil Shear

In its sixteenth version, this commonly acclaimed publication has developed and multiplied into the ‘Drug Eruptions and Reactions handbook’ (D.E.R.M.) – an authoritative consultant to adversarial drug reactions and response styles. With enhanced adverse-events directory and a brand new type procedure for response styles, Litt’s D.E.R.M. is a precious source for someone facing drug prescription. The intuitive search for structure and complete assurance make it a useful diagnostic relief for scientific practitioners and an immense reference software for educators, academics, pharmacists and scholars. In maintaining its designated specialise in drug eruptions, that is a lot liked by way of dermatologists, this version can also be crucial for an individual discovering, educating and working towards cutaneous drugs.

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M. M. M. M. M. M. com for access to Fixed eruption Seizures Somnolence (2001): Pedrosa Gil F+, Pharmacopsychiatry 34(6), 259 Tardive dyskinesia (2007): Masdrakis VG+, Prog Neuropsychopharmacol Biol Psychiatry 31(2), 586 (2006): Fountoulakis KN+, Schizophr Res 88(1-3), 232 (1993): Dove FB, Hosp Pract Off Ed 28, 14 Lymphoid hyperplasia Gastrointestinal/Hepatic (1995): Crowson AN+, Arch Dermatol 131, 925 Abdominal pain Necrosis (1999): Fogarty BJ+, Burns 25, 768 Endocrine/Metabolic Petechiae Photosensitivity (<1%) Galactorrhea Gynecomastia Weight gain (2006): Gentile S, Drug Saf 29(4), 303 (2006): Papadimitriou GN+, Int Clin Psychopharmacol 21(3), 181 Genitourinary Impotence Acne Allergic reactions (<1%) Anaphylactoid reactions/Anaphylaxis Angioedema (2006): Gaig P+, J Investig Allergol Clin Immunol 16(5), 321 Erythema Erythema annulare centrifugum (1999): Garcia-Doval I+, Cutis 63, 35 Erythroderma (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Exanthems Exfoliative dermatitis Facial edema 30 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Rash Urticaria Vasculitis Hair Alopecia (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 196 (passim) Mucosal (1995): Loesche WJ+, J Am Geriatr Soc 43, 401 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (2002): Prescrire Int 11(60), 111 Purpura Sialorrhea Stomatitis Anticonvulsant hypersensitivity syndrome Edema (1995): Crowson AN+, Arch Dermatol 131, 925 (1995): Magro CM+, J Am Acad Dermatol 32, 419 Ageusia Bromhidrosis Dysgeusia (>10%) Glossitis Oral mucosal eruption Sialopenia Skin (2006): Gaig P+, J Investig Allergol 16(5), 321 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1988): Warnock JK+, Am J Psychiatry 145, 425 Pseudolymphoma Note: Limbitrol is amitriptyline and chlordiazepoxide (1995): Feder R, J Clin Psychiatry 56, 35 Pigmentation (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1988): Larrey D+, Gastroenterology 94, 200 Trade names: Amineurin; Domical; Elavil (AstraZeneca); Laroxyl; Lentizol; Levate; Limbitrol (Valeant); Novotriptyn; Saroten; Tryptanol; Tryptizol Indications: Depression Category: Antidepressant, tricyclic; Muscarinic antagonist Half-life: 10–25 hours Clinically important, potentially hazardous interactions with: amprenavir, clonidine, ephedra, epinephrine, eucalyptus, guanethidine, iobenguane, isocarboxazid, linezolid, MAO inhibitors, paroxetine, phenelzine, quinolones, sparfloxacin, St John’s wort, tranylcypromine DRESS syndrome (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1996): Taniguchi S+, Am J Hematol 53, 49 Pruritus AMITRIPTYLINE (1979): Herschthal D+, Arch Dermatol 115, 499 (2000): Milionis HJ, Postgrad Med J 76, 361 Lichen planus Lupus erythematosus Asthenia Tremor Dermatitis Dermatitis herpetiformis Diaphoresis (1–10%) Hypersensitivity (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Neuromuscular/Skeletal Bullous dermatitis (<1%) (2005): Dan Mitchel, Thomasville, GA (from Internet) (observation) (1998): McCarthy J, Ft.

5 hours Note: This drug has been withdrawn Only licensed for use in female patients Skin Acne (<1%) Allergic reactions (<1%) Bacterial infections Folliculitis (<1%) Hematoma (<1%) Jaundice (2005): Turgeon DK+, J Clin Gastroenterol 39(7), 641 Mucosal Dysgeusia (<1%) Parosmia (<1%) Gastrointestinal/Hepatic Mucosal Abdominal pain Dysgeusia (<1%) Parosmia (<1%) Sialorrhea (<1%) Xerostomia (1%) (2005): Turgeon DK+, J Clin Gastroenterol 39(7), 641 Other Death (2002): Balbisi EA, Am J Health Syst Pharm 59(22), 2184 (2004): Andresen V+, Drug Saf 27(5), 283 Cardiovascular Chest pain (2002): Mathew NT+, Headache 2002 Jan; 42(1), 32 (2%) Central Nervous System Chills (<1%) Depression (<1%) Headache (2005): Burstein R+, Pain.

M. M. com for access to Fixed eruption Seizures Somnolence (2001): Pedrosa Gil F+, Pharmacopsychiatry 34(6), 259 Tardive dyskinesia (2007): Masdrakis VG+, Prog Neuropsychopharmacol Biol Psychiatry 31(2), 586 (2006): Fountoulakis KN+, Schizophr Res 88(1-3), 232 (1993): Dove FB, Hosp Pract Off Ed 28, 14 Lymphoid hyperplasia Gastrointestinal/Hepatic (1995): Crowson AN+, Arch Dermatol 131, 925 Abdominal pain Necrosis (1999): Fogarty BJ+, Burns 25, 768 Endocrine/Metabolic Petechiae Photosensitivity (<1%) Galactorrhea Gynecomastia Weight gain (2006): Gentile S, Drug Saf 29(4), 303 (2006): Papadimitriou GN+, Int Clin Psychopharmacol 21(3), 181 Genitourinary Impotence Acne Allergic reactions (<1%) Anaphylactoid reactions/Anaphylaxis Angioedema (2006): Gaig P+, J Investig Allergol Clin Immunol 16(5), 321 Erythema Erythema annulare centrifugum (1999): Garcia-Doval I+, Cutis 63, 35 Erythroderma (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Exanthems Exfoliative dermatitis Facial edema 30 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Rash Urticaria Vasculitis Hair Alopecia (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 196 (passim) Mucosal (1995): Loesche WJ+, J Am Geriatr Soc 43, 401 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (2002): Prescrire Int 11(60), 111 Purpura Sialorrhea Stomatitis Anticonvulsant hypersensitivity syndrome Edema (1995): Crowson AN+, Arch Dermatol 131, 925 (1995): Magro CM+, J Am Acad Dermatol 32, 419 Ageusia Bromhidrosis Dysgeusia (>10%) Glossitis Oral mucosal eruption Sialopenia Skin (2006): Gaig P+, J Investig Allergol 16(5), 321 (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1988): Warnock JK+, Am J Psychiatry 145, 425 Pseudolymphoma Note: Limbitrol is amitriptyline and chlordiazepoxide (1995): Feder R, J Clin Psychiatry 56, 35 Pigmentation (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1988): Larrey D+, Gastroenterology 94, 200 Trade names: Amineurin; Domical; Elavil (AstraZeneca); Laroxyl; Lentizol; Levate; Limbitrol (Valeant); Novotriptyn; Saroten; Tryptanol; Tryptizol Indications: Depression Category: Antidepressant, tricyclic; Muscarinic antagonist Half-life: 10–25 hours Clinically important, potentially hazardous interactions with: amprenavir, clonidine, ephedra, epinephrine, eucalyptus, guanethidine, iobenguane, isocarboxazid, linezolid, MAO inhibitors, paroxetine, phenelzine, quinolones, sparfloxacin, St John’s wort, tranylcypromine DRESS syndrome (1999): Garcia-Doval I+, Cutis 63, 35 (passim) (1996): Taniguchi S+, Am J Hematol 53, 49 Pruritus AMITRIPTYLINE (1979): Herschthal D+, Arch Dermatol 115, 499 (2000): Milionis HJ, Postgrad Med J 76, 361 Lichen planus Lupus erythematosus Asthenia Tremor Dermatitis Dermatitis herpetiformis Diaphoresis (1–10%) Hypersensitivity (1999): Garcia-Doval I+, Cutis 63, 35 (passim) Neuromuscular/Skeletal Bullous dermatitis (<1%) (2005): Dan Mitchel, Thomasville, GA (from Internet) (observation) (1998): McCarthy J, Ft.

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