By Russel O. Potts

Presents an up to date and significant exam of biophysical thoughts utilized in the research of molecular mechanisms underlying transdermal drug supply in addition to a actual and chemical overview of the stratum corneum worthy for the enhancement of percutaneous drug delivery. displays the hands-on adventure of verified and novel researchers within the box.

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AndWeiner, N. Topicaldelivery enhancement with multilamellar liposomes into pilosebaceous units: I. In vitro evaluation using fluorescent techniques with the hamster ear model. J . Invest. Dermatol. 99(1):108-113, 1992. 46. Bodd6, H. ,Kruithof, M. , Brussee, J. and KoertenH. K. Int. J. Pharm. 53:13-24, 1989. 47. , Brussee, and BoddC, H. Int. J . Pharmaceut. 52:47-54, 1989. 48. Stoughton, R. Enhanced percutaneous penetration with l-dodecylazccycloheptan2-one. Arch. Dermatol. 118:474-477, 1982. 49.

Electron Microscopy To date, Monteiro-Riviere andco-workers [60] have published the only studies using electron microscopy to examine the mechanism of iontophoretic transport. 4%) in vivo in pigs for 1 hr (current density: 200 pA/cm2) and subsequently exposed the biopsies to ammonium sulfide vapor to precipitate and localize the mercury, similar to earlier passive transport studies [28]. The micrographs revealed that mercuric chloride traverses intracellularly through the fiist few layers and intercellularly through the remainder of the stratum corneum.

Moreover, the total skin resistance was inversely proportional to the number of PB deposits on the epidermal skin surface. When current was appliedfor 2 hours at the maximum current density (200 pA/cm2), the average density of “pores” (874 f 138/cm2),as determined by SECM, was not significantly different from the average density of hair follicles (760 f 150/cm2) assessed by optical microscopy. This suggests, therefore, that the 28 Turner and Nonato A) 7 SECMimage andopticalimage (B) acquiredoverthesame1-mm2 regionofhairlessmouseskinvisualizethe real-time iontophoreticdepositionof Fe(CN)4 at a current density of40 pA/cm2.

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