By Anna Catania

This booklet represents the joint attempt of a world staff of scientists who're on the vanguard of analysis within the box. the amount spans details on chemistry, pharmacology, distribution, and healing capability of melanocortins. A recurrent subject of this quantity is the position performed by means of special melanocortin receptors in mediating melanocortin results. even if those receptors were pointed out and well-characterized, info within the publication shows that sure categorization in their expression and serve as in several stipulations nonetheless wishes significant paintings

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Additional info for Melanocortins: Multiple Actions and TherapeuticPotential

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The melanotropins: chemistry, physiology and mechanisms of action. 1988; 1-439. Karger: Basel. 2. Chakraborty AK, Funsaka Y, Slominski A et al. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochim Biophys Acta 1996; 313:130-8. 3. Slominski A, Wortsman J, Luger T et al. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000; 80:979-1020.

23. Castrucci AML, Hadley ME, Sawyer TK et al. a-Melanotropin: The minimal active sequence in the lizard skin bioassay. Gen Comp Endocrinol 1989; 73:157-163. 24. Haslach EM, Schaub JW, Haskell-Luevano C. b-Turn secondary structure and melanocortin ligands. Bioorg Med Chem 2009; 17:952-958. 25. Haskell-Luevano C, Rosenquist Å, Souers A et al. Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the b-turn. J Med Chem 1999; 42:4380-4387.

40. Todorovic A, Holder JR, Bauzo RM et al. N-terminal fatty acylated His-DPhe-Arg-Trp-NH2 tetrapeptides: Influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes. J Med Chem 2005; 48(9):3328-3336. 41. Chaturvedi DN, Knittel JJ, Hruby VJ et al. Synthesis and biological actions of highly potent and prolonged acting biotin-labeled melanotropins. J Med Chem 1984; 27:1406-1410. 42. Chaturvedi DN, Hruby VJ, Castrucci AM et al. Synthesis and biological evaluation of the superagonist [Na-Chlorotriazinylaminofluorescein-Ser1, Nle4, D-Phe7]-a-MSH.

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