By Simon P. Fricker (auth.), Simon P. Fricker (eds.)

The discovery of the antitumour job of cisplatin in 1965 and its next advent into medical trials in 1971 used to be the catalyst for an enormous foreign study attempt investigating the possibility of steel compounds in melanoma treatment. Cisplatin now occupies a big position within the armamentarium of the oncologist because of its effectiveness within the remedy of testicular melanoma. A moment new release analogue, carbo­ platin, deals lowered toxicity including healing job, which supplies it a spot within the front-line remedy of genitourinary cancers. those and different successes have inspired the quest for novel metal-based medicinal drugs for melanoma remedy. learn has proven that steel compounds have power for job not just as cytotoxic antitumour brokers, but in addition in components resembling adjuvant remedy, analysis and immunotherapy. the purpose of this ebook is to study and describe the key achievements and advancements bobbing up from this overseas examine attempt. The contributing authors come from labora­ tories all through Europe and the USA and characterize the numerous disci­ plines attribute of this study, akin to scientific learn, pharmacology, tumour biology and inorganic medicinal chemistry.

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Haiduc, I. and Silvestru, C. (1989) Rhodium, iridium, copper and gold antitumour organometallic compounds. In Vivo, 3, 285-94. Hall, T. G. and Schaiff, R. A. B. (1993) Update on the medical treatment of hypercalcemia of malignancy. Clin. , 12, 117-25. Harder, H. C. and Rosenberg, B. (1970) Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein synthesis in mammalian cells in vitro. Int. J. Cancer, 6, 207-16. Harrap, K. R. (1985) Preclinical studies identifying carboplatin as a viable cisplatin alternative.

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A. eta!. (1991) Some substitution reactions of ligands coordinated to the bis(cyclopentadienyl)-titanium moiety, the X-ray crystal structure of Ti (1Js-CsHsh(OPhh and an assessment of the anti-tumour activity of some cyclopentadienyl titanium compounds. Polyhedron, 10(16), 1847-56. Keck, M. V. and Lippard, S. J. (1992) Unwinding of supercoiled DNA by platinum-ethidium and related complexes. J. Am. Chem. , 114, 3386-90. Kelland, L. , Abel, G. and Harrap, K. R. (1992a) Human ovarian carcinoma cell lines and companion xenografts: a disease oriented approach to new platinum anticancer drugs.

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