By Kjerstin M. Owens, J. S. Modica-Napolitano, Keshav K. Singh (auth.), Leslie Costello, Keshav Singh (eds.)

Nearly a century of medical examine has printed that mitochondrial disorder is among the most typical and constant phenotypes of melanoma cells. a few awesome transformations within the mitochondria of standard and melanoma cells were defined. those contain ameliorations in mitochondrial metabolic task, molecular composition of mitochondria and mtDNA series, in addition to in alteration of nuclear genes encoding mitochondrial proteins. This booklet, Mitochondria and Cancer, edited through Keshav ok. Singh and Leslie C. Costello, provides thorough analyses of mitochondrial disorder as one of many hallmarks of melanoma, discusses the medical implications of mitochondrial defects in melanoma, and as targeted mobile objectives for novel and selective anti-cancer therapy.

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell, 18: 283–293. Kahn, B. , and Hardie, D. G. 2005. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab, 1: 15–25. Kim, J. , Semenza, G. , and Dang, C. V. 2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab, 3: 177–185. Ko, Y. , Pedersen, P. , and Geschwind, J. F. 2001.

1995) and activating the expression of most enzymes of the glycolytic pathway including LDHA (Semenza et al. 1994; Firth et al. 1995). Furthermore, the active HIF-dimer induces the expression of growth factors mediating enhanced angiogenesis and erythropoesis (Semenza and Wang 1992; Maxwell et al. 1997). , conditions of normal oxygen partial pressure on the cellular level. However, when oxygen supply is low due to impaired blood flow or inadequate vascularization, HIF1a degradation is inhibited, leading to increased transcription factor activity 28 M.

The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: A quantitative study using laser-captured microdissected tissues. Gynecol. Oncol. 98:104–110 Warburg, O. 1930. Metabolism of Tumors. Arnold Constable, London, UK Warburg, O. 1956. On the origin of cancer cells. Science 123:309–314 Weinhouse, S. 1955. Oxidative metabolism of neoplastic tissue. Adv. Cancer Res. B. 1996. In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function.

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