By Evan Y. Yu M.D., William C. Hahn M.D., PH.D. (auth.), Nadir R. Farid (eds.)
Thyroid melanoma exhibits the quickest price of raise in girls within the united states. there's an pressing have to greater comprehend its underlying explanations, discover effective and delicate equipment for its analysis, new equipment of remedy and follow-up, in keeping with the new advances in know-how.
Molecular foundation of thyroid melanoma brings jointly top-flight specialists from around the globe to contemplate current cutting-edge remedy and methods and what the longer term holds. The fabricated from this attempt is worthy to endocrinologists, quite people with an curiosity within the thyroid, molecular oncologists, nuclear medication physicians and people in biotechnology rationale on devising leading edge treatments for cancer.
"Significant advances in our realizing of thyroid melanoma have happened over the former decade. this article discusses the molecular adjustments and pathologic manifestations obvious during this illness. exceptional investigators handle either the fundamental biology and scientific matters pertinent to our realizing and administration of sufferers with thyroid cancer."
Steven T. Rosen, M.D.
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Extra info for Molecular Basis of Thyroid Cancer
Cancer Res 59, 3855–3860 (1999). 170. , Hurteau, J. , Bigsby, R. , Nephew, K. P. DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol Oncol 82, 299–304 (2001). 171. Vertino, P. , Yen, R. , Baylin, S. B. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransfererase. Mol Cell Biol 16, 4555–4565 (1996). 172. , Issa, J. , Herman, D. , et al. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
One morphologic subtype of Hürthle cell papillary carcinoma which, because of a characteristic cystic change and extensive lymphocytic infiltration into the cores of the papillae of the tumour, has a striking histological resemblance to papillary cystadenoma lymphomatosum of the salivary gland and has been called “Warthin-like tumour of the thyroid” (178). This lesion occurs in the setting of chronic lymphocytic thyroiditis, predominantly in women, and is associated with a similar prognosis to usual papillary carcinoma.
This suggestion 47 of aggressive behaviour may be attributed to inclusion of tall cell variant papillary carcinoma in the group of Hürthle cell carcinomas. One morphologic subtype of Hürthle cell papillary carcinoma which, because of a characteristic cystic change and extensive lymphocytic infiltration into the cores of the papillae of the tumour, has a striking histological resemblance to papillary cystadenoma lymphomatosum of the salivary gland and has been called “Warthin-like tumour of the thyroid” (178).
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