By Wolter J. Mooi, Thomas Krausz
This authoritative reference paintings and useful bench booklet offers an intensive clinico-pathologic research of melanocytic problems, in addition to potent useful information within the analysis of challenge lesions. The authors, either well known specialists in surgical pathology of tumors, expansively talk about scientific and microscopic features of a really huge spectrum of melanocytic lesions. Key diagnostic beneficial properties in addition to strength pitfalls are highlighted in reader-friendly tables, facilitating quickly reference in a hectic diagnostic pathology perform. Pertinent updated references are incorporated and the index has been meticulously compiled.
From reports of the former edition:
'I strongly suggest this booklet to every body drawn to benign or malignant melanocytic disorders'. The New England magazine of Medicine
'Any histopathologist or histopathology division with dermis biopsies to document must have a duplicate of this book.' Histopathology
'This e-book is unquestionably a true develop for the diagnostic pathologist and that i could suggest it to all departments: it could actually develop into the traditional textual content on pigmented lesions' The Bulletin of the Royal collage of Pathologists
'I stumbled on the ebook a excitement to read. It is to be hugely steered for all regimen pathological departments; these facing purely occasional instances will simply locate assistance and reassurance; these departments facing huge numbers will locate it worthwhile within the more odd case.' The magazine of Pathology
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Additional info for Pathology of Melanocytic Disorders
374) and distant metastases, indicating stage IV disease, may be removed either to confirm the tumor stage or for therapeutic reasons. For diagnosis, FNA cytological examination will usually suffice. Distant metastases may be resected with the aim of prolonging survival or alleviating pain or discomfort. Depending on the size of the specimen and the metastasis, it is wholly embedded or blocks are selected from areas with different macroscopic appearances, and where surgical margins are narrowest, after inking these margins.
9 The biopsy should preferably reach the subcutis, so that if the lesion happens to extend deeply into the skin, its base is available for histological investigation. As a rule, punch biopsy and incisional biopsy are inappropriate. 10,11 There are other compelling arguments in favor of excisional biopsy. 1. Second, excisional biopsy constitutes definitive treatment if the lesion is benign, whereas incomplete removal of a benign nevus may result in a recurrence with an atypical appearance (p. 81), leading to diagnostic difficulties that would have been avoided, had the lesion been removed in its entirety.
A statement about the completeness of excision of the lesion should be included, not only in melanomas but preferably also in nevi, in view of the irregularly shaped and sometimes atypical recurrences occasionally encountered after incomplete removal of a nevus (p. 81). • 35 • Techniques and practical considerations When describing the morphology of the lesion, one should avoid interpretative terms, such as ‘primitive’, ‘immature’, ‘active’, ‘irritated’, and so on. The description of histological features should be based on purely morphological terminology.
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