By J. M. Polak, S. R. Bloom (auth.), Professor Dr. Klaus Havemann, George Sorenson MD, Priv. Doz. Dr. Claus Gropp (eds.)
The occurrence of lung melanoma has reached epidemic proportions through the civilized international. One indication of the scale of this challenge is that during the USA lung melanoma has develop into the top reason for melanoma demise in girls in addition to males. In 1912 there has been a "nearly entire consensus of opinion that fundamental malignant neoplasms of the lung (were one) of the rarest sorts of disease," in accordance with Adler. by means of 1937, notwithstanding, it had develop into transparent that the occurrence of lung melanoma used to be expanding considerably; this raise has been revolutionary ever considering the fact that. it really is now popular that a few lung cancers supply upward push to a number of hormones which, now and then, produce medical manifestations. The organization of hormone creation with a "nonendocrine" tumor increases many questions, the solutions to which can shed a few gentle at the etiology of this conventional kind of melanoma. This interesting prob lem has encouraged a large choice of experiences in either the medical and the fundamental sciences. some of the newer stories during this box have been mentioned on the foreign Symposium on Peptide Hor mones and Lung melanoma held in Marburg, West Germany, on June 18-20, 1984. This quantity includes the papers that have been pre sented in this occasion.
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Extra info for Peptide Hormones in Lung Cancer
In: Reznick-Schuller HM (ed) Comparative respiratory tract carcinogenesis, vol II. CRC Press, Boca Raton, pp 161-187 Becker KL, Snider RH, Moore CF, et al (1979) Calcitonin in extrathyroidal tissues of man. Acta Endocrinol(Copenh)92:746-751 Becker KL, Nash DR, Silva OL, et al (1981) Increased serum and urinary calcitonin in pulmonary disease. Chest 79:211-216 Becker KL, Silva OL, Snider RH, et al (1984) The pathophysiology of pulmonary calcitonin. In: Becker KL, Gazdar AF (eds) The endocrine lung in health and disease.
The rat ACTH precursor has been shown to have two possible N-glycosylation sites (Fig. 2). J. Bennett in the y- MSH sequence is complete, the asparagine found within ACTH itself is only partially glycosylated. mRNA translation, ER insertion, cleavage of the signal peptide, and core glycosylation are thought to be completed within 5 min of the initiation of translation. Certainly all these processes are complete by the time the maturing protein is transferred via small transport vesicles to the Golgi apparatus where the N-linked oligosaccharides are further modified ( < 20 min).
For instance, the precursor of the adrenal medulla enkephalin precursor (proenkephalin A) has two possible N-linked glycosylation sites but the precursor has been shown not to be glycosylated (Kilpatrick et al. 1983). The rat ACTH precursor has been shown to have two possible N-glycosylation sites (Fig. 2). J. Bennett in the y- MSH sequence is complete, the asparagine found within ACTH itself is only partially glycosylated. mRNA translation, ER insertion, cleavage of the signal peptide, and core glycosylation are thought to be completed within 5 min of the initiation of translation.
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