By H. David Humes, Vo D. Nguyen, Deborah A. Hunt (auth.), Shaul G. Massry, Michel Olmer, Eberhard Ritz (eds.)

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Clin. Invest. 50:2079, 1971. Using a guinea pig anti-porcine PTH antiserum labelled bovine PTH and human parathyroid serum as standard, compared 54 patients with PAP with 18 patients with "Hyperparathyroidism due to non-parathyroid cancer" (authors' designation). The PHP patients had lower serum calcium, 15X higher IPTH and 8 of the non PHP patients had no detectable IPTH. saw very different RIA slopes for both groups. They Concluded that PTH-like material in "ectopic" hyperparathyroid i sm is immunol ogicall y d i f ferent from PHP patients.

45) Gaillard, Schweiz. Med. Wochschr. 87: Supple 14, P 217, 1957. First to obtain bone resorption by the direct addition of purified parathyroid hormone to bone grown in tissue culture. 1958 46) Lloyd and Rose. Lancet 2:1258, 1958. 11easured total and ionized Ca++ in PHP and non PHP hypercalcemic disorders. They found that ionized Ca++ was disproportionately elevated in PHP in contrast to other hypercalcemic disorders. Also in 2 cases of PHP where total calcium was normal, ionized Ca++ was still elevated.

2 years, concluded with the case for medical management. However 11, or 16%, with hypertension (150/100) at start increased to 16 or 50% at end of study. 101) Ontjes, Mahaffee and Wells. Metabolism 30:406, 1981. Found that with human parathyroid tissue in vitro normal (4), adenoma (18), and noninvolved glands (5) from adenoma patient, adenoma had reduced sensitivity to suppression of parathyroid cyclic ~~p with calcium elevation, and reduced capacity for stimulatin of adenyl cyclase of parthyroid cells by guany-5-yl-imidodiphosphate.

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