By Warwick L. Morison

With a better emphasis at the simple rules, functional concepts, and economics of phototherapy, the 3rd variation is still the normal resource at the UV therapy of pores and skin disease-presenting an elevated variety of case reports, scientific suggestions, and therapy protocols for a transparent realizing of the current and destiny nation of phototherapy, photochemotherapy, and phototesting within the dermatologic enviornment.

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Extra resources for Phototherapy and Photochemotherapy for Skin Disease, Third Edition (Basic and Clinical Dermatology)

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The term is used clinically in two ways. First, when a photosensitizing chemical in combination with nonionizing radiation produces a sunburn-type reaction in the skin, this is referred to as phototoxic response. The reaction is due to direct damage to the skin; it does not involve the immune system and can be produced in all people. , erythema, edema, and pruritus, following exposure to UV radiation alone. Photoallergy This is a state of specifically altered reactivity to an exogenous chemical in which photons play some role.

Covering half of the body and continuing treatment on the other side can rapidly confirm or refute the diagnosis. Determination of the Minimal Urticarial Dose The minimal urticarial dose (MUD) is an essential guide to selecting a starting dose in the treatment of solar urticaria. It is the least exposure dose Phototesting 41 required to produce urticaria within minutes of exposure of small areas of skin to the waveband selected for treatment. Obviously, if a routine schedule of treatment is used and the starting dose exceeds the MUD, the patient is likely to develop a whole-body hive with hypotension and potentially disastrous consequences.

Measurement in photobiology has recently been undergoing change, and although medical photobiology has been slow to follow, the change will certainly occur. The alteration is that the international standard unit of surface area is the meter and not the centimeter. Thus, the conversions are 1 J/ cm2 ¼ 104 J/m2 and 1 mJ/cm2 ¼ 10 J/m2. INTERACTIONS OF PHOTONS AND MATTER Photons interact with matter in a very complex manner and most of this detail is beyond the scope of this book. However, there are a few concepts that have importance in therapy.

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