By M. K. Gospodarowicz, P. Hermanek, D. E. Henson (auth.), Professor Dr. Dr. h.c. P. Hermanek, Dr. Mary K. Gospodarowicz, Dr. D. E. Henson, Dr. R. V. P. Hutter, Dr. L. H. Sobin (eds.)

M. okay. Gospodarowicz, P. Hermanek, and D. E. Henson realization to techniques in melanoma remedy has tended to eclipse the significance of prognostic evaluate. despite the fact that, the popularity that prognostic components usually have a better effect on consequence than on hand remedies and the proliferation of biochemical, molecular, and genetic markers have led to renewed curiosity during this box. the end result in sufferers with melanoma is dependent upon a mixture of diverse components. almost immediately, the main widely known are the level of disorder, histologic kind of tumor, and therapy. it's been recognized for your time that extra elements additionally impression final result. those comprise histologic grade, lymphatic or vascular invasion, mitotic index, functionality prestige, indicators, and so much lately genetic and biochemical markers. it's the target of this quantity to bring together these prognostic components that experience emerged as very important determinants of final result for tumors at a number of websites. This compilation represents the 1st part of a extra huge approach to combine all prognostic components in melanoma to additional improve the prediction of final result following remedy. sure concerns encompass­ ing the evaluation and reporting of prognostic components also are thought of. significance of Prognostic components Prognostic components in melanoma frequently have a big impact on end result, whereas therapy usually has a miles weaker influence. for instance, the effect of the presence of lymph node involvement on survival of sufferers with metastatic breast melanoma is far more than the impact of adjuvant therapy with tamoxifen within the comparable crew of sufferers [5].

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Retrospective multivariate analysis of 216 patients with a median follow-up of 11 years. Acta Radiol 24: 17-24 43. Thoresen SO, Akslen LA, Glattre E et al (1989) Survival and prognostic factors in differentiated thyroid cancer - a multivariate analysis of 1055 cases. Br J Cancer 59: 231-235 44. Trump DL, Mendelsohn G, Baylin SB (1979) Discordance between plasma calcitonin and tumor-cell mass in medullary thyroid carcinoma. N Engl J Med 301: 253-255 45. Tubiana M, Sch1umberger M, Rougier P et al (1985) Long-term results and prognostic factors in patients with differentiated thyroid carcinoma.

The inference is that pathologic findings in lymph nodes are better predictors of outcome than clinical findings. Histologic Features There are conflicting data on the prognostic significance of histologic grading. Gamel and Jones [IS] found that the degree of differentiation was second only to nodal stage as a prognostic factor for tumor cure, but its influence on survival was not significant. Langdon et al. [25] were unable to demonstrate any effect of histologic grade on local recurrence, but noted that poorly differentiated tumors were more likely to give rise to lymph node metastases.

Arch Otolaryngol Head Neck Surg 117: 1251-1256 10. Fu KK, Leibel SA, Levine ML et al (1977) Carcinoma of the major and minor salivary glands. Cancer 40: 2882-2890 II. Guillamondegui 0 M, Byers RM, Luna MA et al (1975) Aggressive surgery in treatment for parotid cancer: the role of adjunctive post-operative radiotherapy. Am J Roentgenol123: 49-54 12. Hermanek P, Sobin LH (eds) (1992) VICC TNM classification of malignant tumours, 4th edn, 2nd rev. Springer, Berlin Heidelberg New York 13. Hunter RM, Davis BW, Gray GF et al (1983) Primary malignant tumours of salivary gland origin.

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