By Elizabeth Fontham, Pelayo Correa (auth.), Walter Troll, Ann R. Kennedy (eds.)

Protease inhibitors (PIs) are commonly allotted in crops and animals, and feature quite a few capabilities, which come with fighting digestion of seeds via bugs and enhancing blood clotting in animals. After it used to be famous that man made and traditional inhibitors suppress two-stage carcinogenesis and breast melanoma, wide paintings investigating PIs as chemopreventive brokers was once all started. PIs are specific in that they intervene with melanoma improvement in a number of methods, together with suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic proof helps their prevention of significant human cancers in populations that devour meals containing them. Their supervised use in people is at the threshold of improvement. The epidemiologic discovery of the significance of lentils and different seeds wealthy in PIs in combating many human cancers allowed us to examine the motion of PIs as chemopreventive brokers, as reviewed in bankruptcy I (Fontham and Correa). bankruptcy 2 (Kennedy) discusses the position of common PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the potential boundaries in their use. In bankruptcy three (Kennedy), the transformation of C3HI lOTlh cells because of cancer agents and promoters is proven to be suppressed by way of PIs. Bowman (Chapter four) relates the invention of inhibitors in soybeans which are detailed from the Kunitz inhibitor, and the prevalence of an identical inhibitor in peanuts and different legumes. bankruptcy five (Birk) is an outline of PIs of plant beginning and their position in human nutrition.

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Extra info for Protease Inhibitors as Cancer Chemopreventive Agents

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Is Soybean-Product-Associated Pancreatic Cancer in Rats the Result of Protease Inhibitors? As discussed in Chapter 18, when rats are fed a diet containing raw, full-fat soybean flour, pancreatic cancer can occur, and carcinogen-induced pancreatic carcinogenesis can be enhanced, but whether the effect is caused by protease inhibitors is not clear. Several studies have suggested that protease inhibitors may be only partially responsible for the deleterious effects of soybeans on the pancreas; for example, Kakade et al.

60 CI + ! ) W ~ 40 >C 0 a:\ 0 - 0 UNTREATED 6. DMH 0111 V III +DIIH <> Sill + DIIH • PIli • PIli + DIIH II 30 20 -5 0 5 10 15 20 25 30 35 40 45 50 55 60 65 TIME (wks) AFTER INITIATION OF EXPERIMENTAL DIETS Figure 30. Growth charts for the animals on cancer chemopreventive diets containing protease inhibitors; none of the diets had an effect on animal body weight, while carcinogenesis was being suppressed in the colon (Fig. 2) and liver (Fig. 8). Details are given in St. Clair et al. (1990). 40 ....

1986). Other anti nutritional substances found in soybeans (and other legumes) include: hemagglutinins (lectins), goitrogens, cyanogens, lathyrogens, phytate (phytic acid), flatulence producers, and gossypol (Liener, 1989). While any or all of these substances could contribute to the growth-suppressing effects of raw soybeans, it is likely that the soybean protein itself is the major factor producing growth suppression (Gallaher and Schneeman, 1986). , 1973). This experiment suggested that much of the growthsuppressing effect was due to the protein itself.

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