By B. Mousson, P. Baltassat (auth.), Chris H. M. M. De Bruyn, H. Anne Simmonds, Mathias M. Müller (eds.)
These volumes, entitled "Purine Metabolism in guy IV" con tain the papers offered on the Fourth foreign Symposium on Human Purine and Pyrimidine Metabolism", held in Maastricht (The Netherlands), June 1982. The court cases of the 3 past meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) have been additionally released through Plenum Press. long ago few years curiosity in purine and pyrimidine metabo lism less than basic and pathological stipulations has been becoming swift ly. except the kind of classical issues resembling hyperuricae mia, medical gout and urolithiasis, more and more papers in terms of different fields were provided at successive conferences. wisdom derived from the learn of purine metabolism with regards to lymphocyte functionality, for example, has spread out new percentages for immunomodulation and leukaemia chemotherapy, with eventual conse quences for different sorts of melanoma. At past conferences there were tips implicating purine metabolism with regards to general cardiac and skeletal muscle functionality. through the current assembly mych new facts on either concerns were re ported which point out transparent ameliorations within the pathways of ATP metabo lism. The widening of the sphere of curiosity can be illustrated through the new paintings on infectious disorder: exploitation of the variations in purine metabolic pathways in convinced parasites in comparison with these in human cells has ended in new rationales for remedy being devel oped.
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Additional info for Purine Metabolism in Man-IV: Part B: Biochemical, Immunological, and Cancer Research
Was not discernable by nondenaturing polyacrylamide gel electrophoresis (Fig. 2). I2 In preparation for comparative subunit molecular weight studies the lymphoblast HPRT enzymes were intrinsically labeled in culture and were purified to radio§gemical homogeneity. Lymphoblast cultures were incubated with S-methionine (40 ~Ci/ml) for 14 h. The radio labeled HPRT enzymes were purified by a three step procedure which included 1) centrifugation at 100,000 xg, 2) incubation at 85 0 C for 15 min, and 3) immunoprecipitation with HPRT polyclonal antibody.
In this paper we describe results which suggest the existence of a catalytically-active monomeric HG-PRTase which functions as an enzyme-metal ion complex. Y. , (St. Louis). Chelex-100, N,N Lmethylenebisacrylamide, N,N,N ',NLtetramethylenediamine and sodium dodecylsulfate were supplied by Bio-Rad (Richmond, CA). ). HG-PRTase was purified from yeast and detected using published procedures (1). 45 46 D. L. SLOAN ET AL. Chemical cross-linking of HG-PRTase was accomplished utilizing the bifunctional reagents, dimethyl suberimidate (4) and glutaraldehyde (5).
Determination of HPRT in intact fibroblasts gave values of 57, 14, and 49% of normal, respectively (9). L. 8 pM. 0 pM. 8 pM measured in erythrocyte lysates. These data indicate that it is possible to carry out kinetic studies of HPRT using intact fibroblasts. The ~ values obtained in control individuals were within 10% of those determined in erythrocyte and fibroblast lysates. 8 (15), and 17 (16). E. A. was virtually the same as the controls. m . E. A. could reflect a higher ~ for phosphoribosy1 pyrophosphate, lower catalytic efficiency, decreased stability, fewer enzyme molecules, or a combination of these effects.
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