By B. C. Giovanella, B. Mondovi (auth.), Prof. Alessandro Rossi-Fanelli, Prof. Renato Cavaliere, Prof. Bruno Mondovì, Prof. Guido Moricca (eds.)

Since the 1st observations of Busch in 1866, the potential use of warmth as a healing agent within the remedy of melanoma has been again and again topic to bursts of curiosity, nearly always by means of sessions of overlook and skepticism. In 1963-1964, this challenge was once back attacked by means of us either from the biochemical and from the scientific issues of view. the 1st result of this joint attempt have been confident past expectation, and generated a brand new revial of stories geared toward the id of the character of the bio­ chemical lesion in addition to on the optimization of method and of the healing schedules hooked up with scientific use. even though the variety of mammalian tumors which were proved to be heat-sensitive is now rather huge, and even though every now and then a correlation has been proven among tumorigenicity and heat-sensitivity of in vitro cultured mobilephone strains, the query of an instantaneous and incessant courting among neoplastic personality and better sensitivity to hyperthermic publicity remains to be open to carrying on with research and reappraisal. a number of experiences deal actually with the selection of the stipulations less than which, in vitro and or in vivo, varied tumors are successfully broken by way of increased temperatures.

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52, 921 (1974) 11. : Criteria of viability in heat-treated cells. EXp. Cell Res. 44, 658 (1966) 12. : Temperature-resistant variants in clonal populations of pig kidney cells. EXp. Cell Res. 46, 301 (1967) 13. : Growth and survival of mammalian cells under continous thermal stress. EXp. Cell Res. 56, 382 (1969) 14. : Reproductive capacity and viability at higher temperatures of various transformed hamster cell lines. J. nat. Cancer Inst. 43, 469 (1969) I 15. : Differential heat response of normal and transformed human cells in tissue culture.

Physiol. 83, 43 (1974) 70. : The behavior of HeLa-S3 cells under the influence of supranormal temperatures. J. Ultrastruct. Res. 34, 375 (1971) 71. : High resolution proton NMR study of an isolated fragment of R17 bacteriophage in RNA. ) 248, 225 (1974) 72. : Calorimetric investigation of the influence of cholesterol on the transmission properties of bilayers formed from synthetic L-~ -lecithins in aqueous suspension. J. biol. Chem. 247, 3697 (1972) 73. : A thermolabile repression system. Cold Spr.

H. ), London: Academic Press, 1967, p. 293 25. : A study of the influence exerted by a variety of physical and chemical forces on the virulence of carcinoma in mice, and of the conditions under which immunity against cancer may be experimentally induced in these animals. Brit. med. J. 2, 1548 (1906) 26. : Studies on the structure and function of the mammalian testis. II. Cytological and histochemical observation on the testis of the rat after a single exposure to heat applied for different lengths of time.

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