By Henry N. Neufeld (auth.), Samuel Sideman D.Sc., Chem.Eng., Rafael Beyar MD, D.Sc. (eds.)

The ultrasound speed tomography permits dimension of cardiac geometries for varied levels within the cardiac cycle. the current tomograph makes reconstruc­ tions at periods of 20 ms. due to an absence of transparent (intramural) landmarks (except the roots of the papillairy muscle), it really is tough to pinpoint spatial trajectories of specific issues within the middle. accordingly, a moment process was once built of injecting radiopaque markers within the middle and following their movement styles through the cardiac cycle with aid of a biplane X-ray gear. the information received with either equipment might be applied in our finite point version of the guts to compute intramural stresses and lines. the implications received sofar with the prolonged Darcy equation to account for the interplay of blood rheology and tissue mechanics glance promising. extra checking out with extra subtle topics than pointed out in determine nine is needed earlier than it will likely be carried out in our finite point version of the center. We finish that evaluation of local cardiac functionality, together with neighborhood myocardial blood circulate, calls for nonetheless an important learn attempt however the effects got sofar justify, to our opinion, a continuation during this path. Acknowledgement The authors recognize Dr. C. Borst and coworkers for doing the animal experiments and prof. Van Campen and dr. Grootenboer for his or her participation is a few facets of this work.

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Physiol Rev 58:1,174-254 Hill A V (1938) The heat of shortening and dynamic constants of muscle. Proc R Soc London, Ser B, 126-136 Hoffman JIE (1978) Determinants and prediction of transmural myocardial perfusion. Circulation 58(3):281-391 Johnson EA (1979) Force interval relationship of cardiac muscle. ) Handbook of Physiology, Sect 2. Am Physiol Soc Bethesda Maryland pp. 475-496 Mirsky I, Ghista ON, Sandler H (1974) Cardiac mechanics physiological clinical and mathematical considerations. John Wiley & Sons Inc New York p 45 Pollack GH, Krueger JW (1978) Myocardial sarcomere mechanics: Some parallels with skelatal muscle.

P 0 I I M I I 0 I I / I I 0 I /1 "' I P 0 / I / I I I • 0 ... J 10L---~--~--~~--~--~--~----~ 80 85 90 95 100 105 110 11 5 LV DIASTOLIC VOLUME (m l) Figure 7. Pressure-volume relations in a patient in control state (_) and following methoxamine infusion (e). Note the dramatic parallel shift upward following the drug infusion. Altering the factors elasticity, geometry, and LV wall mass individually did not reproduce the methoxamine curve. 45 quite apparent that alterations of these factors individually do not result in a P-V relation that closely approximates the post methoxamine curve.

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