By Peter M. Elias, Kenneth R. Feingold

A must have reference for any researcher or scientist attracted to cutaneous protecting mechanisms, this advisor offers expertly researched chapters on each element of stratum corneum constitution, functionality, and improvement, in addition to specified sections on barrier-repair options and the position of barrier functionality in illnesses corresponding to atopic dermatitis, psoriasis, and ichthyosis.

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In: Montagna W, ed. The Epidermis. , 1964. 4. Szakall A. Experimentelle daten zus kla¨rung der funktion der wasser barrier in epidermis des lebinden. Menschen-Berufsdermatosen 1958; 6:171. 5. Winsor T, Burch GE. Rate of invisible perspiration through living and dead stratum corneum. Arch Int Med 1944; 74:437. 6. Monash H. Location of the superficial barrier to skin penetration. J Invest Derm 1957; 29:367. 7. Malkinson FD. Studies of the percutaneous absorption of C14 labeled steroid by use of the gas flow cell.

Ultrastructure of Normal and Abnormal Skin. Philadelphia: Lea & Febiger, 1967:54–75. 7. Elias PM, Brown BE, Fritsch P, Goerke J, Gray GM, White RJ. Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum. J Invest Dermatol 1979; 73:339–348. 8. Gray GM, Yardley HJ. Different populations of pig epidermal cells: isolation and lipid composition. J Lipid Res 1975; 16:441–447. 9. Wertz PW, Downing DT. Covalently bound omega-hydroxyacylsphingosine in the stratum corneum.

The most widely accepted hypothesis about the role of the SC acid mantle is in antimicrobial defense (30). Pathogenic bacteria, such as S. aureus, grow best at a neutral pH, while conversely, normal flora (coagulase-negative staphylococci, propionibacteriae) grow ↓ Lipid Synthesis ? ↓ LB Production ↓ Corneodesmosomes ↓ Barrier Function ↓ SC Integrity/Cohesion Figure 3 Psychologic stress and glucocorticoids rapidly compromise epidermal function. 10 Elias best at a more acidic pH (30). The potential importance of pH for antimicrobial function is underscored in neonatal skin, which displays a neutral pH coupled with an enhanced risk of infection, as well as inflammation, impaired SC integrity/ cohesion, and a subtle barrier abnormality (31).

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