By Raluca Dumitru, Guang Hu (auth.), M.A. Hayat (eds.)

Volume eleven during this sequence discusses healing purposes of stem cells in disorder and tissue harm. assurance contains pluripotent stem cells, that may supply upward push to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, that may generate all cells in a specific lineage and unipotent stem cells, that could supply upward push to just one phone sort. This quantity additionally examines melanoma stem cells, tumor-initiating cells which possesses the ability of self-renewal and will supply upward thrust to the heterogeneous lineages of melanoma cells that contain the tumor. assurance extends to molecular mechanisms underlying the derivation and enlargement of human embryonic stem cells, the function of particular proteins within the upkeep and inhibition of extraembryonic differentiation of those cells and the function of signaling chargeable for the self-renewal of mouse embryonic stem cells. 9 chapters talk about the medical significance of melanoma stem cells, encompassing glioma, leukemia, ovarian melanoma, pediatric sarcomas and head and neck squamous mobile carcinoma. The function of melanoma stem cells is additionally elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous telephone carcinoma. The e-book is going directly to survey healing program of stem cells of hematopoietic and non-hematopoietic foundation for regeneration of bones, together with in osteoporotic bone affliction; to light up the appliance of hematopoietic stem cells in bone regeneration and to debate their use as a biomarker to facilitate decision of a remedy. The members overview cells as biomarkers for pediatric sturdy tumors, and weigh the benefits and barriers of hematopoietic stem telephone transplantation. additionally integrated are info of neural stem mobile engraftment within the injured spinal twine; the regenerative capability of neural stem/progenitor cells of newborns and melanoma gene remedy capability utilizing neural stem cells. just like the previous volumes within the sequence, this booklet is unique for its entire procedure, its unusual roster of fifty eight individuals representing 10 varied nations and its thorough evaluate of modern know-how and methods.

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Extra resources for Stem Cells and Cancer Stem Cells, Volume 11: Therapeutic Applications in Disease and injury

Sample text

Primitive Endoderm Differentiation .......................... 4 4 6 6 6 7 7 7 7 7 8 8 The CCR4-Not Complex ......................................... Structure and Organization of the Complex ........................................................... Molecular Function of the CCR4-Not Complex ............ 9 10 CCR4-Not in ESC Maintenance ............................. 11 Concluding Remarks ............................................... 12 References .................................................................

Nat Methods 8:424–429 Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F, Ng HH (2010) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468:316–320 13 Collart MA (2003) Global control of gene expression in yeast by the Ccr4-Not complex. Gene 313:1–16 Collart MA, Panasenko OO (2012) The Ccr4–not complex. Gene 492:42–53 Dejosez M, Zwaka TP (2012) Pluripotency and nuclear reprogramming.

11 Concluding Remarks ............................................... 12 References ................................................................. 13 R. Dumitru Human Pluripotent Stem Cell Core, University of North Carolina at Chapel Hill, 109 Mason Farm Road, 406 Taylor Hall, Chapel Hill, NC 27599, USA G. gov 8 Embryonic stem cells (ESCs) are defined by their capacity to self-renew and differentiate into all adult tissues. They hold the promise to generate models for human development and disease, establish new platforms for drug discovery, and develop therapies for regenerative medicine.

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