By Parmeggiani Pier Luigi

This booklet goals at offering biologists and clinicians with a compact description of the physiological manifestations of sleep which are major from the perspective of the main of homeostasis. within the jargon of the physiological literature, the note "homeostasis", brought via W.B. Cannon (1926), refers back to the life of a continuing country of extracellular physique fluids in regards to their actual and chemical houses. seeing that common cellphone functionality relies on the fidelity of such fluids, in multicellular animals there are lots of regulatory mechanisms below the keep an eye on of the primary apprehensive method that act to keep up the fidelity of the interior setting. The experimental learn of homeostasis in wakefulness already printed the character and complexity of the underlying physiological mechanisms. a lot of those regulatory mechanisms set off compensatory alterations in accordance with the main of damaging suggestions. by contrast, the regulate of homeostasis throughout sleep states remains to be a subject matter less than debate referring to its physiological endurance and importance. The author's goal is to discover the explicit mechanistic proofs of the particular consistency or inconsistency of the primary in numerous states of sleep. during this admire, there are numerous interacting physiological features that should be tested around the sleep states. the choice of the main major experimental facts is conducted with the intention to current an easy yet no longer simplistic method of the difficulty. The ebook brings forth the proof that the systemic homeostatic legislation of many physiological variables underlying mobile existence isn't lively in a specific kingdom of the ultradian sleep cycle in mammals. It additionally indicates the theoretical and useful significance of the primary of homeostasis, as a criterion of the systemic characterisation of the integrative keep an eye on of physiological capabilities by means of the crucial worried approach in the course of sleep in mammals.

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Extra resources for Systemic Homeostasis and Poikilostasis in Sleep: Is REM Sleep a Physiological Paradox?

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The modulation in sleep of gastrointestinal and renal functions is not considered in this book since it does not fit within the strict temporal criterion of the homeostasis–poikilostasis dichotomy in the ultradian cycle of sleep. In addition, the sleep-state-dependent changes in the secretion of somatotropin, prolactine, thyrotropin, gonadotropins and the hormones underlying the hydromineral balance, cannot be simply considered the result of the alternation between homeostasis and poikilostasis.

1986; Mancia and Zanchetti, 1980). , 1999) was observed. , 1994). , 1983) in REM sleep. , 1989). In conclusion, the actual cardiac output is the result of a poor correlation between heart rate, stroke volume and arterial blood pressure, associated with tonic and phasic changes in vascular conductance. , 1991). , 1982), as mentioned in Chapter 5. qxd 10/27/2010 5:48 PM Page 37 b1046 Systemic Homeostasis and Poikilostasis in Sleep Circulation in Sleep 37 The variability of cardiovascular phenomena is not simply the direct result of changes in the central regulation of the autonomic outflow; it is also loosely associated with bursts of rapid eye movements, myoclonic twitches, ponto-geniculo-occipital waves and breathing irregularities.

15 mA, 5 msec, 10/sec). EEG, electroencephalogram; PG, pneumogram; NREMS, NREM sleep; REMS, REM sleep. , 1973, 1976). qxd 10/22/2010 1:35 PM Page 27 b1046 Systemic Homeostasis and Poikilostasis in Sleep Respiration in Sleep 27 than the threshold temperature of tachypnea. The tachypnea elicited by preoptic-anterior hypothalamic warming during NREM sleep immediately disappears with the advent of an episode of REM sleep even though the preoptic-anterior hypothalamic temperature is still above the NREM sleep threshold of the respiratory response.

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