By A. G. Messenger (auth.), Julian L. Verbov JP, MD, FRCP. FIBiol (eds.)

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Cholestyramine, an ionexchange resin, has been used in severe cases of cholestasis, but it has not been established that it is safe in pregnancy. THE EFFECT OF PREGNANCY ON SKIN DISORDERS Pregnancy has an unpredictable effect on many skin disorders. 1. 1 Skin diseases influenced by pregnancy Tendency to improve Variable effect Tendency to deteriorate Atopic eczema Psoriasis Alopecia areata Sarcoidosis Acne Malignant melanoma Pityriasis rosea Erythema nodosum Candidosis Condylomata acuminata Ehlers-Danlos syndrome Neurofibromatosis Systemic lupus erythematosus Pustular psoriasis Modified from Winton, G.

Acta Dermatol. Venereol. ) 64, 26-30 27. Peeroboom-Wynia, J. D. , Stolz, E. and Prins, M. E. F. (1986). Markers of immunologic injury in progressive alopecia areata. J. Cutan. , 13,363-369 28. Wiesner-Menzel, L. and Happle, R. (1984). Intrabulbar and peri bulbar accumulation of dendritic OKT6-positive cells in alopecia areata. Arch. Dermatol. , 276, 333-334 29. , Hamm, H. and Happle, R. (1987). Abnormal expression of Class I and Class II major histocompatibility antigens in alopecia areata: modulation by topical immunotherapy.

S. (1981). Alopecia areata and autoimmunity. Br. f. , 105,153-157 15. Du Vivier, A. and Munro, D. D. (1975). Alopecia areata, autoimmunity and Down syndrome. Br. Med. , 1, 191-192 16. Carter, D. M. and Jegasothy, B. V. (1976). Alopecia areata and Down's syndrome. Arch. , 112, 1397-1399 17. Ikeda, T. (1965). A new classification of alopecia areata. Dermatologica, 131, 421-445 18. Chase, H. , Rauch, H. and Smith, V. W. (1951). Critical stages of hair development and pigmentation in the mouse. Physiol.

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