By Sakari Reitamo;Thomas A. Luger;Martin Steinhoff

This accomplished new textbook from a global line-up of members seems to be in any respect the treatment plans for atopic dermatitis, together with the fascinating new pharmaceutical ideas.

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S. 1). 2 T = T-cells M = Mast cells As an additional factor, autoallergens amplify the immunologic reactions in AD patients. S. aureus superantigens are presented as ‘ordinary’ antigens in the peptide-presenting groove of the major histocompatibility complex MHC to the respective antigen-specific T cell. On the other hand, the intact proteins are capable of bridging the MHC complex to all T cells with the same β-chain family, irrespective of their antigen specificity. 39 In most of the AD patients specific IgE antibodies against staphylococcal superantigens could be found, which correlate with disease severity.

Lancet 1996; 348: 581–3. 15. Mao XQ, Shirakawa T, Enomoto T, Shimazu S, Dake Y et al. Association between variants of mast cell chymase gene and serum IgE levels in eczema. Hum Hered 1998; 48: 38–41. 16. Tanaka K, Sugiura H, Uehara M, Sato H, Hashimoto-Tamaoki T et al. Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease. Clin Exp Allergy 1999; 29: 800–3. 17. Kawashima T, Noguchi E, Arinami T, Kobayashi K, Otsuka F et al.

Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population. Hum Hered 2001; 51: 177–9. 19. Soderhall C, Bradley M, Kockum I, Wahlgren CF, Luthman H et al. Linkage and association to candidate regions in Swedish atopic dermatitis families. Hum Genet 2001; 109: 129–35. 20. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR et al. 1 markers and total serum immunoglobulin E concentrations. Science 1994; 264: 1152–6. 21. Kawashima T, Noguchi E, Arinami T, Yamakawa-Kobayashi K, Nakagawa H et al.

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