By William E. Stewart II (auth.)

This publication is an replace of Interferon, released in 1969 by way of Dr. Jan Vilcek. the sphere of interferon learn has considering the fact that increased from its former slim therapy of interferon strictly as an antiviral substance, such that The Interferon process now encompasses mobile modulations starting from immune changes to phone proliferative regulations to antitumor actions. The gradually expanding variety of those non-antiviral services of interferons emphasizes the necessity for a complete - and demanding - evaluate of the full literature of interferon experiences. The textual content, with its assisting bibliography, offers entire insurance of interferon examine. A newcomer to the world should still locate right here all of the informa­ tion essential to comprehend why interferon, which has been studied for greater than two decades and which initially stirred pleasure over its medical professionals­ pects, continues to be inspiring hypothesis approximately this strength. For these already fa­ miliar with the doubtless perpetual scientific promise of interferon, this quantity may still function a priceless reference resource, the biggest bibliography at the topic ever to seem lower than one conceal. in actual fact, this ebook may be thought of simply as an creation to the subject and as a reference resource; such a lot questions about the interferon procedure are nonetheless unanswered - even unasked. expectantly this summation and significant evalua­ tion of labor performed so far will stimulate and facilitate additional progress.

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1975, 1976) + Rinaldo (1976); Sokhey, Soloviev and Vasilieva (1977) VI. Protozoa Bensonita jellisona + Remington and Merigan (1969) + Encepbalitozoon cuniculi Armstrong et al. (1973) Eperytbrozoon coccoides + Suntharasami and Rytel (1973) Plasmodium bergbei + Huang, Schultz, and Gordon (1968) Toxoplasma gondii + Trypanosoma cruzi + Rytel and Jones (1966); Freshman et al. , 1968, 1970; Buck, Chain and Himmelweit, 1971). Interferon induction has also been reported with extracts of the edible mushrooms Lentinus edodes and Cortinelluf shiitake; again the active component was found to be a double-stranded RNA (Tsunonada and Ishida, 1970; F.

It is apparent that inducer viruses can be either single-stranded RNA viruses, doublestranded RNA viruses, or DNA viruses. The majority of virus es that have been tested can induce interferon in the intact animal or in cell cultures. Interferon-like substances have also been reported to be produced by mosquito cells infected with arbovirus (Enzmann, 1973); however, this report could not be confirmed by others (Takehara, 1975a, b; Murray and Morahan, 1973). To date, interferon production seems to be reliably demonstrated only in vertebrates and their cells.

Coli endotoxin produced interferon. Ho (1964) found interferon in rabbits injected with live E. coli or endotoxin. It is important to note that while Youngner and Stinebring reported this interferon to be acid stable (to pH 3), Ho found the E. coli and endotoxin-induced interferons were labile at pH 2. Interferon was also induced in mice by Brucella (Hallum, Youngner, and Stinebring, 1965), and rats made interferon when inoculated with E. coli (Desomer and Billiau, 1966). Interferon was found in the aqueous humor, urine and cerebrospinal fluids of rabbits inoculated with Salmonella typhosa endotoxin (Oh, 1966; Oh and Gill, 1966).

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