By Michael Khan, Stella Pelengaris

This complete textual content offers an in depth review of the molecular mechanisms underpinning the improvement of melanoma and its therapy. Written by way of a world panel of researchers, experts and practitioners within the box, the textual content discusses all elements of melanoma biology from the reasons, improvement and analysis via to the remedy of melanoma.
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* a good textual content for upper-level classes within the biology of melanoma, for clinical scholars and certified practitioners getting ready for larger assessments, and for researchers and academics within the box

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This number is often referred to as the Hayflick limit. Cellular senescence is associated with aging and longevity and has also been termed replicative senescence. The Hayflick limit for dividing cells may in part be determined by the length of the cells’ telomeres (see Chapter 9). Telomeres are noncoding regions at the tips of chromosomes. Cell division requires the duplication of chromosomes, but each time a chromosome reproduces itself, it loses a part of the telomere (telomere attrition). Once a cell’s telomeres reach a critically short length, the cell can no longer replicate its chromosomes and thus will stop dividing.

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