By Jonathan Hadgraft

Completely revised, the second one version of Transdermal Drug supply provides discussions of the foremost matters pertinent to transdermal drug supply. masking the intensity and breadth of the sphere, from actual chemistry and evaluate of drug permeability to to be had enhancement applied sciences, to regulatory approval, the booklet examines themes essential to the serious review of a drug candidate's strength for supply around the dermis. It describes how you can confirm the transdermal permeability of gear, how rationally to pick applicants for transdermal supply, easy methods to select chemical and/or actual the right way to improve epidermis shipping, and the way to unravel regulatory issues.

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In this chapter, 22 different equations are compared to the large number of permeability coefficient values collected by Flynn (1). II. A. Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. SC lipids. The availability, appealing physical interpretation, and relative success in describing a wide range of biological processes make molecular weight (MW) and logarithmically transformed octanol–water partition coefficients (log K ow) by far the most widely used parameters for predicting skin penetration.

D. The Predictors log K ow and MW Permeability coefficients and log K ow are both affected by chemical ionization. Permeability coefficient values measured for ionized compounds are lower Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. than permeability coefficients measured for nonionized compounds (4,9,39,40). log K ow values measured with both ionized and nonionized species present, and without correction for ionization, are lower than log K ow values measured when only nonionized chemical is present, because the ionized form has a higher water solubility.

Additionally, measurements for ionized compounds were included. For example, Wilschut et al. (20) chose to include the permeability coefficient values measured for the 100% ionized form rather than the nonionized form for six drugs (diclofenac, diethylamine salicylate, indomethacin, naproxen, piroxicam, and salicylic acid), although Singh and Roberts (42) reported experimental values for both. The relevance of log K ow determined for the nonionized compound with permeability coefficients determined for the ionized compound is questionable.

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