By Kazumasa Kurosumi (auth.), P. M. Motta M.D., Ph.D. (eds.)

Innovative microscopic thoughts, brought over the last twenty years, have contributed a lot to making a brand new photo of the dynamic structure of the mobile, which may now be extra precisely correlated with particular biochemical and physiopathological occasions. those advancements have ended in major advances in our realizing of the physiomorphological and pathological facets of the secretory mechanism, in addition to the pharmacologic equipment used to regulate, experimentally, the functionality of exocrine and endocrine glands. the combination of latest ultrastructural tools corresponding to freeze-fracture/etching, immunocytochemistry, scanning and high-voltage electron microscopy, cytoautoradiography, and so on. , has confirmed to be of serious price whilst utilized to the research of endocrine cells and tissues. simply because details in this subject has seemed in a number of clinical and scientific journals, this ebook: (1) studies the result of an integrative process proposing a entire ultrastructural account of the most points of the sector; (2) issues out gaps or arguable issues in our wisdom; and (3) outlines pertinent instructions for destiny learn. The chapters, ready by way of famous experts within the box, current conventional details at the subject in a concise demeanour and, with a worthy number of unique illustrations, express what the mixing of latest microscopic equipment can give a contribution to the topic when it comes to new innovations. This quantity can be worthy to phone biologists, anatomists, embryologists, histologists, pharmacologists, pathologists, and, after all, endocrinologists. it is going to even be of curiosity to scholars, practitioners of drugs, and to all others facing medical learn and diagnosis.

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5) Nucleoluslike body (nematosome) in a rat PT specific glandular cell (x 11,200). 31 paratus, generally conspicuous, occupies a large jux- ridae PT where the specific cells are the only glandular tanuclear area where several small sacculo-vesicular cell type present. complexes are scattered. Dense secretory vesicles (DSV), abundant in the mouse (Figs. 2. Gonadotrophic cells scarce in other species (Figs. 3, 6) in which they accu- Numerous cells with ultrastructural characteristics mulate only in a few cells.

Shiino M, Rennels EG: Vinblastine-induced microtubular paracrystals in prolactin cells of anterior pituitary gland of lactating rats. Am J Anat 144(3): 399-405, 1975. ) C R Acad Sc Paris 290(5): 711-714, 1980. Herbert DC: Intercellular junctions in the rhesus monkey pars distalis. Anat Rec 195(1): 1-6, 1979. Theret C, Tamboise E: Etude ultrastructurale des rapports experimentau x entre les cellules alpha et des fibres neurovegetatives dans l'adenohypophyse. Ann Endoc Paris 24(3): 421-440, 1963.

In estrogenized animals, a hyperplasia of this cell type is evident on electron micrographs (68). Specific antibodies against PRL stain positively the secretory granules. 3. Opiocortico-melanotropic cells The functional significance of this cell type depends upon investigations using immunocytochemical techniques. Initially demonstrated by light microscopy, the localization of the immunoenzyme reaction in the secretory granules is now well established by electron microscopy. Pelletier et al. (III) have reported in the rat pituitary gland that antibodies against ACTH and P-LPH bound to the same granules.

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